genome search | EU-SAGE

Genome-editing techniques are promising tools in plant breeding. To facilitate a more comprehensive understanding of the use of genome editing, EU-SAGE developed an interactive, publicly accessible online database of genome-edited crop plants as described in peer-reviewed scientific publications.
The aim of the database is to inform interested stakeholder communities in a transparent manner about the latest evidence about the use of genome editing in crop plants. Different elements including the plant species, traits, techniques, and applications can be filtered in this database.
Regarding the methodology, a literature search in the bibliographic databases and web pages of governmental agencies was conducted using predefined queries in English. Identifying research articles in other languages was not possible due to language barriers. Patents were not screened.
Peer-reviewed articles were screened for relevance and were included in the database based on pre-defined criteria. The main criterium is that the research article should describe a research study of any crop plant in which a trait has been introduced that is relevant from an agricultural and/or food/feed perspective. The database does neither give information on the stage of development of the crop plant, nor on the existence of the intention to develop the described crop plants to be marketed.
This database will be regularly updated. Please contact us via the following webpage in case you would like to inform us about a new scientific study of crops developed for market-oriented agricultural production as a result of genome editing

Displaying 45 results

Traits related to biotic stress tolerance

Reduced aphid damage to improve crop resistance to aphids or other insects. Restrict aphid sucking on watermelon.
( Li et al., 2021 )

SDN1
CRISPR/Cas

Beijing Academy of Agricultural and Forestry Sciences, China

Increased resistance to drought stress by enhancing antioxidant capacity and defence system.
( Gao et al., 2022 )

SDN1
CRISPR/Cas

Henan Agricultural University
China Tobacco Sichuan Industrial Co., China

Oomycete resistance: significantly reduced susceptibility to downy mildew disease (DM). DM is caused by Peronospora belbahrii, a worldwide threat to the basil industry.
(Zhang et al., 2021)

SDN1
CRISPR/Cas

The State University of New Jersey, USA

Enhanced resistance to downy mildew pathogen.
( Hasley et al., 2021 )

SDN1
CRISPR/Cas

University of Hawaii at Manoa, USA

Viral resistance: enhanced Potato virus Y (PVY) resistance. PVY infection can result in up to 70% yield loss globally.
(Le et al., 2022)

SDN1
CRISPR/Cas

Vietnam Academy of Science and Technology, Vietnam
University of Edinburgh, UK

Enhanced resistance to powdery mildew.
( Wang et al., 2022 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences Institute of Tobacco Research, China

Fungal resistance: Fusarium oxysporum f.sp. niveum (FON), one of the most devastaging diseases affecting watermelons. FON progresses along xylem vessels, causing the hollow and dried-out stems.
(Zhang et al., 2020)

SDN1
CRISPR/Cas

Jiangsu Academy of Agricultural Sciences
Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement, China

Viral resistance: highly resistant to viral infection with beet severe curly top virus (BSCTV), a geminivirus that can cause serious damage to many crop plants.
(Ji et al., 2015)

SDN1
CRISPR/Cas

University of Chinese Academy of Sciences, China

Viral resistance: Attenuated infection symptoms and reduced viral RNA accumulation, specific for the cucumber mosaic virus (CMV) or tobacco mosaic virus (TMV).
(Zhang et al., 2018)

SDN1
CRISPR/Cas

South China Agricultural University, China
University of Missouri, USA

Viral resistance: resistance to potato virus Y (PVY), one of the most economically and scientifically important plant viruses, causing damaging diseases of cultivated tobacco around the world.
(Ruyi et al., 2021)

SDN1
CRISPR/Cas

Mudanjiang Teachers College
Jilin Normal University
Mudanjiang Tobacco Research Institute, China

Viral resistance: to Cotton Leaf Curl Kokhran Virus, causing Cotton leaf curl disease (CLCuD), a very devastating and prevalent disease. CLCuD causes huge losses to the textile and other industries.
(Hamza et al., 2021)

SDN1
CRISPR/Cas

National Institute for Biotechnology and Genetic Engineering, Pakistan

Viral resistance: increased resistance against Tobacco Mosaic Virus (TMV).
(Jogam et al., 2023)

SDN1
CRISPR/Cas

Kakatiya University
Center of Innovative and Applied Bioprocessing (DBT-CIAB), India
University of Minnesota
East Carolina University, USA

Fungal resistance: enhanced resistance to Golovinomyces cichoracearum, which causes powdery mildew.
(Wang et al., 2023)

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences
Linyi Tobacco Company
Tobacco Research Institute of Hubei Province
China Tobacco Hunan Industrial Co., China

Oomycete resistance: resistance against downly mildew disease (DM). DM is caused by Peronospora belbahrii, a worldwide threat to the basil industry.
(Laura et al., 2023)

SDN1
CRISPR/Cas

Research Centre for Vegetable and Ornamental Crops
Institute of Agricultural Biology and Biotechnology
Institute for Sustainable Plant Protection
Research Centre for Olive Fruit and Citrus Crops
University of Pisa
Center for Agricultural Experimentation and Assistance
Institute of Biosciences and Bioresources, Italy

Sensitive and specific visual detection method for Acidovorax citrulli, an important seed-borne disease of the cucurbits.
( Wang et al., 2024 )

SDN1
CRISPR/Cas

Fuyang Normal University
Anhui Jianzhu University
Southern Subtropicals Grops Research Institute, China

Viral resistance: improved resistance against a tobamovirus, which could threaten tomato, tobacco, potato and squash plants.
(Miyoshi et al., 2024)

SDN1
CRISPR/Cas

Ehime University
Ehime Research Institute of Agriculture, Japan

Traits related to abiotic stress tolerance

Improved Cadmium (Cd)-tolerance by reducing the Cd transport from vacuole to cytosol in tobacco leaves.
( Jia et al., 2022 )

SDN1
CRISPR/Cas

Henan Agricultural University
Xiamen University, China

Increased drought tolerance.
( Xu et al., 2023 )

SDN1
CRISPR/Cas

R&
D Center of China Tobacco Yunnan Industrial Co. Ltd.
Sichuan Agriculture University, China

Enhanced resistance to drought stress with increased osmotic adjustment, antioxidant activity, photosynthetic efficiency and decreased water loss rate.
( Liu et al., 2023 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences
Tobacco Research Institute
Key Laboratory of Tobacco Genetic Improvement and Biotechnology
Shenzhen Yupeng Technology Co.
Sichuan Tobacco Corporation, China

Reduced cadmium (Cd) accumulation and enhanceed Cd resistance. Cd accumulation in the edible parts of the plant pose potential risks to human health.
( Zheng et al., 2024 )

SDN1
CRISPR/Cas

Zhengzhou Tobacco Research Institute of CNTC
China Tobacco Yunnan Industrial Co. LTD
Beijing Life Science Academy (BLSA)
Zhengzhou University, China

Traits related to improved food/feed quality

Ultra-low nicotine level
( Burner et al., 2022 )

SDN1
CRISPR/Cas

North Carolina State University, USA

Improved cadmium tolerance by reducing the Cd transport from vacuole to cytosol in tobacco leaves.
( Jia et al., 2022 )

SDN1
CRISPR/Cas

Henan Agricultural University
Xiamen University, China

Increased sucrose content.
( Ren et al., 2020 )

SDN1
CRISPR/Cas

Beijing Key Laboratory of Vegetable Germplasm Improvement
Capital Normal University
China Agricultural University, China
Cornell University
Robert W. Holley Center for Agriculture and Health, USA

Decreased seed size and promoted seed germination. To improve consumer experience for flesh-consumed watermelons, no (or small and sparse) seeds are better because the flesh portion is larger.
( Wang et al., 2021 )

SDN1
CRISPR/Cas

Beijing Key Laboratory of Vegetable Germplasm Improvement, China

Reduced nicotine levels.
Nicotine is an addictive compound leading to severe diseases.
( Singh et al., 2023 )

SDN1
CRISPR/Cas

CSIR-National Botanical Research Institute
Academy of Scientific and Innovative Research (AcSIR)
Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), India

Increased potassium concentrations (K+). Potassium is crucial for improving the quality of tobacco.
( Gao et al., 2024 )

SDN1
CRISPR/Cas

Yunnan Academy of Tobacco Agricultural Sciences/National Tobacco Genetic Engineering
Research Center
Chinese Academy of Agricultural Sciences, China

Reduced nicotine levels. Nicotine is the addictive component in tobacco.
( Jeong et al., 2024 )

SDN1
CRISPR/Cas

Nulla Bio Inc.
Gyeongsang National University
Gyeongsang National University 501 Jinju-daero, South Korea

Traits related to increased plant yield and growth

Significantly higher potassium accumulation. Potassium ions are essential nutrients for growth and development of tobacco.
( Gao et al., 2024 )

SDN1
CRISPR/Cas

Yunnan Academy of Tobacco Agricultural Sciences/National Tobacco Genetic Engineering Research Center
Chinese Academy of Agricultural Sciences, China

Dwarfing phenotype.
( Sun et al., 2024 )

SDN1
CRISPR/Cas

Northwest A&
F University
Guangdong Academy of Agricultural Sciences
Shanxi Agricultural University, China

Traits related to industrial utilization

Cytoplasmic male sterility.
( Chang et al., 2022 )

SDN1
CRISPR/Cas

Northwest Institute of Plateau Biology Chinese Academy of Sciences, China

Establishment of maternal haploid induction. Doubled haploid technology is used to obtain homozygous lines in a single generation. This technique significantly accelerates the crop breeding trajectory.
( Zhong et al., 2022 )

SDN1
CRISPR/Cas

China Agricultural University, China
Wageningen University and Research, The Netherlands

Male sterility.
( Zhang et al., 2021 )

SDN1
CRISPR/Cas

Northwest A&
F University, China

Accumulate low levels of alkaloids. Nicotine is the most abundant alkaloid produced in tobacco plants. Switching to cigarettes containing levels of nicotine below the level of sustaining an addiction response will smoke less and/or find it easier to quit. Possibly, the US Food and Drug Administration (FDA) may mandate such reductions in future cigarette products.
( Smith et al., 2022 )

SDN1
CRISPR/Cas

North Carolina State University, USA

Gynoecious phenotype: only female flowers. Advantageous trait for production of hybrid seed by bees under spatial isolation, because it avoids hand emasculation and hand pollination.
(Zhang et al., 2019)

SDN1
CRISPR/Cas

Beijing Key Laboratory of Vegetable Germplasm Improvement
Chinese Academy of Agricultural Engineering Planning and Design, China

Manipulation of self-incompatibility.
( Zhang et al., 2020 )

SDN1
CRISPR/Cas

Chinese Academy of Sciences, China
Aarhus University
DLF Seeds A/S, Denmark

Glycoproteins without plant-specific glycans. Plants or plant cells can be used to produce pharmacological glycoproteins, for example antibodies or vaccines. However these proteins carry N-glycans with plant-typical residues [β(1,2)-xylose and core α(1,3)-fucose]. This plant-specific glycans can greatly impact the immunogenicity, allergenicity, or activity of the protein.
( Mercx et al., 2017 )

SDN1
CRISPR/Cas

Université catholique de Louvain
Université de Liège, Belgium

Nicotine-free tobacco.
( Schachtsiek et al., 2019 )

SDN1
CRISPR/Cas

TU Dortmund University, Germany

SDN1
CRISPR/Cas

Beijing Key Laboratory of Vegetable Germplasm Improvement, China

Traits related to herbicide tolerance

Tribenuron
( Tian et al., 2018 )

Beijing Academy of Agriculture and Forestry Sciences
China Agricultural University, China

Traits related to product color/flavour

Color change of the taproot from orange to pink-orange and slightly higher content of α-carotene in the taproot.
( Li et al., 2022 )

SDN1
CRISPR/Cas

Nanjing Agricultural University
Chinese Academy of Agricultural Science, China

Albino phenotype.
( Huang et al., 2022 )

SDN1
CRISPR/Cas

Chinese Academy of Forestry, China

Albino phenotype. Diversity in fruit color. Watermelon is an important fruit croup throughout the world.
( Tian et al., 2016 )

SDN1
CRISPR/Cas

Beijing Key Laboratory of Vegetable Germplasm Improvement
China Agricultural University
Beijing University of Agriculture, China

Purple color.
( Xu et al., 2019 )

SDN1
CRISPR/Cas

Nanjing Agricultural University, China

Color modification due to reduced anthocyanin accumulation.
( Klimek-Chodacka et al., 2018 )

SDN1
CRISPR/Cas

University of Agriculture in Krakow, Poland
East Carolina University
University of Maryland, USA

Pale purple phenotype due to dramatic decrease of anthocyanins content.
( Duan et al., 2023 )

SDN1
CRISPR/Cas

College of Horticulture, China

Traits categories

Genome Editing Technique

Countries

Plant

Sdn Type

Traits related to biotic stress tolerance

Traits related to abiotic stress tolerance

Traits related to improved food/feed quality

Traits related to increased plant yield and growth

Traits related to industrial utilization

Traits related to herbicide tolerance

Traits related to product color/flavour