genome search | EU-SAGE

Genome-editing techniques are promising tools in plant breeding. To facilitate a more comprehensive understanding of the use of genome editing, EU-SAGE developed an interactive, publicly accessible online database of genome-edited crop plants as described in peer-reviewed scientific publications.
The aim of the database is to inform interested stakeholder communities in a transparent manner about the latest evidence about the use of genome editing in crop plants. Different elements including the plant species, traits, techniques, and applications can be filtered in this database.
Regarding the methodology, a literature search in the bibliographic databases and web pages of governmental agencies was conducted using predefined queries in English. Identifying research articles in other languages was not possible due to language barriers. Patents were not screened.
Peer-reviewed articles were screened for relevance and were included in the database based on pre-defined criteria. The main criterium is that the research article should describe a research study of any crop plant in which a trait has been introduced that is relevant from an agricultural and/or food/feed perspective. The database does neither give information on the stage of development of the crop plant, nor on the existence of the intention to develop the described crop plants to be marketed.
This database will be regularly updated. Please contact us via the following webpage in case you would like to inform us about a new scientific study of crops developed for market-oriented agricultural production as a result of genome editing

Displaying 37 results

Traits related to biotic stress tolerance

Fungal resistance: Reduced pathogenicity to the oomycete Phytophthora palmivora, a destructive pathogen that infects all parts of papaya plants. Increased papain sensitvity of in-vitro growth. Papaya fruits contain papain, a cysteine protease that mediates plant defense against pathogens and insects.
(Gumtow et al., 2018)

SDN1
CRISPR/Cas

University of Hawaii at Manoa, USA

Fungal resistance: increased resistance to both biotrophic and necrotrophic plant pathogenic fungi, Bipolaris spot blotch and Fusarium root rot.
(Galli et al., 2022)

SDN1
CRISPR/Cas

Justus Liebig University, Germany

Mutants were compromised in infectivity of Phytophthora palmivora, a destructive oomycete plant pathogen with a wide host range
( Pettongkhao et al., 2022 )

SDN1
CRISPR/Cas

Prince of Songkla University, Thailand
University of Hawaii at Manoa
East-West Center, USA
Sainsbury Laboratory Cambridge University (SLCU), UK

Viral resistance: Increased resistance to the barley mild mosaic virus (BaMMV), which can cause yield losses as high as 50% upon infection.
(Hoffie et al., 2022)

SDN1
CRISPR/Cas

Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK)
Federal Research Centre for Cultivated Plants, Germany

Viral resistance: Highly efficient resistance against wheat dwarf virus (WDV), an economically important virus. WDV infect both wheat and barley causing severe yield losses. The natural resistance resources are limited.
(Kis et al., 2019)

SDN1
CRISPR/Cas

University of Pannonia
Hungarian Academy of Sciences
Eötvös Loránd University University
Szent István University, Hungary

Rapid detection system for Paracoccus marginatus, an insect that can cause huge crop losses.
( Chen et al., 2024 )

SDN1
CRISPR/Cas

Fujian Academy of Agricultural Sciences, China
UMR ISA, France

Traits related to abiotic stress tolerance

Increased tolerance to salinity stress. Development of lines with reduced inositol hexakisphosphate (IP6) content may enhance phosphate and mineral bioavailability. ICP6 is a major storage form of phosphate in cereal grains.
( Vicko et al., 2020 )

SDN1
CRISPR/Cas

Czech Academy of Sciences, Czech Republic

Increased salt-tolerance.
( Antonova et al., 2024 )

SDN1
CRISPR/Cas

Institute of Plant and Animal Ecology (IPAE)
N.I. Vavilov All-Russian Institute of Plant Genetic Resources (VIR)
Institute of Cytology and Genetics (ICG), Russia

Traits related to improved food/feed quality

Increased grain hardness and reduced grain width. Grain hardness index of hina mutants was 95.5 on average, while that of the wild type was only 53.7, indicating successful conversion of soft barley into hard barley.Grain hardness, defined as the resistance of the kernel to deformation, is the most important and defining quality of barley and wheat.
( Jiang et al., 2022 )

SDN1
CRISPR/Cas

Qinghai Normal University
Chinese Academy of Sciences, China

Specific differences in grain morphology, composition and (1,3;1,4)-β-glucan content. Barley rich in (1,3;1,4)-β-glucan, a source of fermentable dietary fibre, is useful to protect against various human health conditions. However, low grain (1,3;1,4)-β-glucan content is preferred for brewing and distilling.
( Garcia-Gimenez et al., 2020 )

SDN1
CRISPR/Cas

The James Hutton Institute
University of Dundee, UK
University of Adelaide
La Trobe University, Australia

Changing grain composition: decrease in the prolamines, an increase in the glutenins, increased starch content, amylose content, and β-glucan content. The protein matrix surrounding the starch granules was increased.
(Yang et al., 2020)

SDN1
CRISPR/Cas

Sichuan Agricultural University, China
Norwich Research Park, UK
CSIRO Agriculture and Food, Australia

Lowering phytate synthesis in seeds. Phytate is an anti-nutritient.
( Vlčko and Ohnoutková, 2020 )

SDN1
CRISPR/Cas

Czech Academy of Sciences, Czech Republic

Lower levels of D hordein. D hordein is one of the storage proteins in the grain, with a negative effect on malting quality.
( Li et al., 2020 )

SDN1
CRISPR/Cas

Qinghai Province Key Laboratory of Crop Molecular Breeding
Chinese Academy of Sciences
University of Chinese Academy of Sciences, China

Reduced content of saturated fatty acids: low palmitic and high oleic acid. Great potential for improving peanut oil quality for human health.
(Tang et al., 2022)

SDN1
CRISPR/Cas

Qingdao Agricultural University, China

Increased vitamin C content, increased oxidation stress tolerance and increased ascorbate content.
( Zhang et al., 2018 )

SDN1
CRISPR/Cas

Chinese Academy of Sciences, China

Improved fatty acid content: high oleic acid, decreased linoleic acid content. FA composition is important for human health and shelf life.
(Wen et al., 2018)

SDN1
TALENs

Guangdong Academy of Agricultural Sciences, China

Glossy sheat phenotype.
( Gerasimova et al., 2023 )

SDN1
CRISPR/Cas

Siberian Branch of the Russian Academy of Sciences
Vavilov Institute of Plant Genetic Resources (VIR)
Siberian Branch of the Russian Academy of Sciences, Russia

Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Germany

Zero amylose grain. Amylose levels significantly influence processing of grain.
( Li et al., 2024 )

SDN1
CRISPR/Cas

Chinese Academy of Sciences
Qinghai University
Qinghai Academy of Agricultural and Forestry
Sciences
Shandong Academy of Agricultural Sciences, China

Reduced levels of very long chain saturated fatty acids in kernels, which are associated with revalance of atherosclerosis and cardiovascular disease.
( Huai et al., 2024 )

SDN1
CRISPR/Cas

Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, China
International Crops Research Institute of the Semi-Arid Tropics (ICRISAT), India
Murdoch University, Australia

Traits related to increased plant yield and growth

High temperature germination. Large increases in the maximum temperature for seed germination to allow for the cultivation of the crop in production areas with higher temperature.
( Bertier et al., 2018 )

SDN1
CRISPR/Cas

University of California, USA

Positive regulation for grain dormancy. Lack of grain dormancy in cereal crops causes losses in yield and quality because of preharvest sprouting.
( Lawrenson et al., 2015 )

SDN1
CRISPR/Cas

Norwich Research Park, UK
Murdoch University, Australia

Rapid improvement of domestication traits and genes that control plant architecture, flower production and fruit size. Major productivity traits are improved in an orphan crop.
( Lemmon et al., 2018 )

SDN1
CRISPR/Cas

Cold Spring Harbor
The Boyce Thompson Institute
Cornell University, USA

Increase in plant height, tiller number, grain protein content and yield. 1.5- to 2.8-fold increase in total chlorophyll content in the flag leaf at the grain filling stage. Delayed senescence by 10–14 days. High nitrogen content in shoots under low nitrogen conditions.
( Karunarathne et al., 2022 )

SDN1
CRISPR/Cas

Murdoch University
Department of Primary Industries and Regional Development, Australia

Enhanced photosynthesis and decreased leaf angles for improved plant architecture and high yields.
( An et al., 2022 )

SDN1
CRISPR/Cas

Huazhong Agricultural University, China

Increased leaf yield of lettuce by delaying the onset of flowering.
( Choi et al., 2022 )

SDN1
CRISPR/Cas

Korea Research Institute of Bioscience and Biotechnology
Korea University of Science and Technology, South Korea

Root growth angle regulation, among the most important determinants of root system architecture. Root growth angle controls water uptake capacity, stress resilience, nutrient use efficiency and thus yield of crop plants.
( Kirschner et al., 2021 )

SDN1
CRISPR/Cas

University of Bonn
University of Cologne
Leibniz Institute of Plant Genetics and Crop Plant Research Gatersleben
Justus-Liebig-University Giessen, Germany
University of Bologna, Italy

Significantly improved photosynthesis and decreased leaf angles. The plant architecture is ideal for dense planting.
( An et al., 2022 )

SDN1
CRISPR/Cas

Huazhong Agricultural University, China

Altered spike architecture.
( de Souza Moraes et al., 2022 )

SDN1
CRISPR/Cas

Wageningen University and Research, The Netherlands
Universidade de São Paulo, Brazil
Norwich Research Park, UK
Rheinische Friedrich-Wilhelms-Universität, Germany

Semi-dwarf phenotype to improve lodging resistance and increased seed dormancy. Increased seed dormancy can be beneficial for use in the malting industry.
( Cheng et al., 2023 )

SDN1
CRISPR/Cas

University of Tasmania
Murdoch University
Department of Primary Industries and Regional Development, Australia
Chinese Academy of Agricultural Sciences, China

Delay in the appearance of flower buds and increased yield.
( Beracochea et al., 2023 )

SDN1
CRISPR/Cas

Consejo Nacional de Investigaciones Científicas Y Técnicas (CONICET)
Instituto Nacional de Tecnología Agropecuaria (INTA), Argentina

Decreased spike rachis node number and increased grain size and weight.
( Fan et al., 2023 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences
Hainan Yazhou Bay Seed Laboratory
Shandong Academy of Agricultural Sciences
China Agricultural University
Hubei Academy of Agricultural Sciences, China

Butterhead plant architecture.
( Xie et al., 2023 )

SDN1
CRISPR/Cas

Huazhong Agricultural University
Wuhan Academy of Agricultural Sciences, China

Traits related to industrial utilization

Conversion of hulled into naked barley.
( Gasparis et al., 2018 )

SDN1
CRISPR/Cas

National Research Institute
Warsaw University of Life Sciences (SGGW), Poland

Improve biofuel production by mediating lignin modification. Lignocellulosic biomasses are an abundant renewable source of carbon energy. Heterogenous properties of lignocellulosic biomass and intrinsic recalcitrance caused by cell wall lignification lower the biorefinery efficiency. Reduced lignin content is desired.
( Lee et al., 2021 )

SDN1
CRISPR/Cas

Korea Institute of Science and Technology (KIST)
University of Science and Technology (UST)
Daejeon, South Korea

Traits related to herbicide tolerance

Herbicide-resistance (ALS-targeting).
( Shi et al., 2023 )

Henan Biological Breeding Center Co.
The Shennong Laboratory, China

Traits related to product color/flavour

Albino phenotype.
( Brewer et al., 2022 )

SDN1
CRISPR/Cas

University of Florida, USA

Traits related to storage performance

Enhanced oleic acid to linoleic acid ratio. This adjusted ratio can improve the shelf life of peanut oil.
( Rajyaguru et al., 2024 )

SDN1
CRISPR/Cas

Junagadh Agricultural University, India

Traits categories

Genome Editing Technique

Countries

Plant

Sdn Type

Traits related to biotic stress tolerance

Traits related to abiotic stress tolerance

Traits related to improved food/feed quality

Traits related to increased plant yield and growth

Traits related to industrial utilization

Traits related to herbicide tolerance

Traits related to product color/flavour

Traits related to storage performance