genome search | EU-SAGE

Genome-editing techniques are promising tools in plant breeding. To facilitate a more comprehensive understanding of the use of genome editing, EU-SAGE developed an interactive, publicly accessible online database of genome-edited crop plants as described in peer-reviewed scientific publications.
The aim of the database is to inform interested stakeholder communities in a transparent manner about the latest evidence about the use of genome editing in crop plants. Different elements including the plant species, traits, techniques, and applications can be filtered in this database.
Regarding the methodology, a literature search in the bibliographic databases and web pages of governmental agencies was conducted using predefined queries in English. Identifying research articles in other languages was not possible due to language barriers. Patents were not screened.
Peer-reviewed articles were screened for relevance and were included in the database based on pre-defined criteria. The main criterium is that the research article should describe a research study of any crop plant in which a trait has been introduced that is relevant from an agricultural and/or food/feed perspective. The database does neither give information on the stage of development of the crop plant, nor on the existence of the intention to develop the described crop plants to be marketed.
This database will be regularly updated. Please contact us via the following webpage in case you would like to inform us about a new scientific study of crops developed for market-oriented agricultural production as a result of genome editing

Displaying 61 results

Traits related to biotic stress tolerance

Highly significant reduction in susceptibility to fire blight, caused by the bacterium Erwinia amylovora. Apple is one of the most cultivated fruit crops throughout the temperate regions of the world.
( Pompili et al., 2020 )

SDN1
CRISPR/Cas

Università degli Studi di Udine
Fondazione Edmund Mach, Italy

Fungal resistance: increased resistance to both biotrophic and necrotrophic plant pathogenic fungi, Bipolaris spot blotch and Fusarium root rot.
(Galli et al., 2022)

SDN1
CRISPR/Cas

Justus Liebig University, Germany

Viral resistance: reduced cotton leaf curl viral (CLCuV) load with asymptomatic plants. <br /> CLCuV causes a very devastating and prevalent disease. It causes huge losses to textile and other industries.
(Shakoor et al., 2023)

SDN1
CRISPR/Cas

University of the Punjab
University of Gujrat, Pakistan
Pacific Biosciences
CureVac Manufacturing GmbH, Germany

Fungal and bacterial resistance: Increased resistance to late blight pathogen Phytophthora infestans, common scab, and the early blight pathogen Alternaria solani.
(Karlsson et al., 2024)

SDN1
CRISPR/Cas

University of Agricultural Sciences, Sweden

Viral resistance: Resistance to Potato Virus Y (PVY), one of the most devastating viral pathogens causing substantial harvest losses.
(Zhan et al., 2019)

CRISPR/Cas

Hubei University
Huazhong Agricultural University, China
Max‐Planck‐Institut für Molekulare Pflanzenphysiologie, Germany

Fungal resistance: Enhanced resistance against powdery mildew, caused by Oidium neolycopersici, which is a major concern for the productivity of tomato plants.
(Li et al., 2024)

SDN1
CRISPR/Cas

University of Torino, Italy
Wageningen University &
Research, The Netherlands
Shanxi Agricultural University, China

Fungal resistance: increased resistance to Phytophthora infestans, causing late blight disease, the most serious disease of potato crops worldwide. The pathogen can infect the leaves, stems and tubers of potato plants. An unprotected field can be completely destroyed in several days.
(Kieu et al., 2021)

SDN1
CRISPR/Cas

Swedish University of Agricultural Sciences, Sweden
University of Copenhagen, Denmark

Fungal resistance: effective reduction of susceptibility against downy mildew by increasing salicylic acid levels. The pathogen can devastate individual vineyards and in some cases also affect production from entire regions.
(Giacomelli et al., 2023)

SDN1
CRISPR/Cas

Research and Innovation Centre
Fondazione Edmund Mach, Italy
Enza Zaden
Hudson River Biotechnology, The Netherlands

Bacterial resistance: enhanced disease resistance to Clavibacter michiganensis subsp. michiganensis infection.
(García-Murillo et al., 2023)

CRISPR/Cas

Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico

Fungal resistance: decreased susceptibility to Ustilago maydis, causing smut. The pathogen causes galls on all aerial parts of the plant, impacting crop yield and quality.
(Pathi et al., 2020)

SDN1
CRISPR/Cas

Leibniz Institute of Plant Genetics and Crop Plant Research, Germany

Fungal resistance: improved sheath blight resistance. Sheath blight disease caused by Rhizoctonia solani AGI-1A and is one of the three major rice diseases. Sheath blight disease can cause severe yield losses.
(Cao et al., 2021)

SDN1
CRISPR/Cas

Agricultural College of Yangzhou University
Jiangsu Yanjiang Institute of Agricultural Science
Yangzhou University
Testing Center of Yangzhou University
Ministry of Agriculture
Chinese Academy of Agricultural Sciences
Institutes of Agricultural Science and Technology Development, China
BASF, Germany

Viral resistance: reduced viral accumulation and amelioration of virus-induced symptoms by Potato Virus Y.
(Lucioli et al., 2022)

SDN1
CRISPR/Cas

ENEA
Council for Agricultural Research and Economics (CREA), Italy
National Agricultural Research and Innovation Centre, Hungary

Oomycete resistance: resistance against downly mildew disease (DM). DM is caused by Peronospora belbahrii, a worldwide threat to the basil industry.
(Laura et al., 2023)

SDN1
CRISPR/Cas

Research Centre for Vegetable and Ornamental Crops
Institute of Agricultural Biology and Biotechnology
Institute for Sustainable Plant Protection
Research Centre for Olive Fruit and Citrus Crops
University of Pisa
Center for Agricultural Experimentation and Assistance
Institute of Biosciences and Bioresources, Italy

Viral resistance: Increased resistance to the barley mild mosaic virus (BaMMV), which can cause yield losses as high as 50% upon infection.
(Hoffie et al., 2022)

SDN1
CRISPR/Cas

Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK)
Federal Research Centre for Cultivated Plants, Germany

Fungal resistance: increased tolerance to Late Blight disease, which could be devastating to tomato yields.
(Maioli et al., 2024)

SDN1
CRISPR/Cas

University of Torino, Italy
Ingeniero Fausto Elio/n, Spain
Wageningen University &
Research,

Fungal resistance: Reduced susceptibility to Verticillium longisporum, fungal pathogen that causes stem striping in Brassica napus and leads to huge yield losses.
(Ye et al., 2024)

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel
Institut für Zuckerrübenforschung
Hohenlieth-Hof, NPZ Innovation GmbH, Germany
Aswan University, Egypt
Fujian Agriculture and Forestry University, China

Fungal resistance: increased resistance to Erysiphe necator, causing powdery mildew in grape cultivar. The pathogen infects all green tissues and berries, leading to dramatic losses in yield and berry quality.
(Malnoy et al., 2016)

SDN1
CRISPR/Cas

Fondazione Edmund Mach, Italy
ToolGen Inc.
Institute for Basic Science
Seoul National University, South Korea

Fungal resistance: resistance to Oidium neolycopersici, causing powdery mildew.
(Nekrasov et al., 2017)

SDN1
CRISPR/Cas

Max Planck Institute for Developmental Biology, Germany
Norwich Research Park, UK

Bacterial resistance: improved resistance to Xanthomonas oryzae, which causes bacterial blight, a devastating rice disease resulting in yield losses.
(Oliva et al., 2019)

SDN1
CRISPR/Cas

International Rice Research Institute, Philippines
University of Missouri
University of Florida
Iowa State University
Donald Danforth Plant Science Center, USA
Université Montpellier, France
Heinrich Heine Universität Düsseldorf
Max Planck Institute for Plant Breeding Research
Erfurt University of Applied Sciences, Germany
Nagoya University, Japan

Fungal resistance: enhanced resistance against rust caused by Puccinia striiformis f. sp. tritici and powdery mildew caused by Blumeria graminis f. sp. tritici., while also increasing yield.
(Liu et al., 2024)

SDN1
CRISPR/Cas

Southwest University
Yangtze University, China
University of Cologne, Germany
University of Maryland

Bacterial resistance: Increased resistance to Erwinia amylovora, causing fire blight disease that threatens the apple and a wide range of ornamental and commercial Rosaceae host plants.
(Malnoy et al., 2016)

SDN1
CRISPR/Cas

Fondazione Edmund Mach, Italy
ToolGen Inc.
Institute for Basic Science
Seoul National University, South Korea

Fungal resistance: reduced susceptibility to Verticillium longisporum, a pathogen causing Verticillium stem striping. No fungicide treatments are currently available to control this disease.
(Pröbsting et al., 2020)

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel
Institut für Zuckerrübenforschung
NPZ Innovation GmbH, Germany

Traits related to abiotic stress tolerance

Enhanced drought tolerance.
( Wang et al., 2023 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences, China
International Maize and Wheat Improvement Center, Mexico

Increased root length, which can restore good performance under water stress.
( Gabay et al., 2023 )

SDN1
CRISPR/Cas

University of California
Howard Hughes Medical Institute, USA
University of Haifa, Israel
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Universidad Nacional de San Martín (UNSAM), Argentina
Fudan University
China Agricultural University, China
Karolinska Institutet, Sweden

Increased drought-avoidance strategy.
( Maioli et al., 2024 )

SDN1
CRISPR/Cas

University of Torino, Italy
Ingeniero Fausto Elio/n, Spain
Wageningen University &
Research, The Netherlands

Improved drought tolerance.
( D'Incà., 2024 )

SDN1
CRISPR/Cas

University Roma Tre
Universit `a di Trieste
IOAG-BIOTECC.R. Casaccia
Sapienza University of Rome
University of Milano
Roma Tre Section
Instituto Nazionale Biostrutture e Biosistemi (INBB)
National Biodiversity Future Center, Italy

Traits related to improved food/feed quality

Improved starch quality. Starch has many food and technical applications and is often modified to certain specifications.
( Andersson et al., 2017 )

SDN1
CRISPR/Cas

Swedish University of Agricultural Sciences, Sweden

Reduction of phytic acid (PA) in seeds. PA has adverse effects on essential mineral absorption and thus is considered as an anti-nutritive for monogastric animals.
( Sashidhar et al., 2020 )

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel
Max-Planck-Institute for Evolutionary Biology, Germany

Mutant cell lines doubled the accumulation level of anthocyanins biosynthesized. The production of these important pigments was stabilized over time.
( D'Amelia et al., 2022 )

SDN1
CRISPR/Cas

National Research Council of Italy
University of Naples Federico II
Council for Agricultural Research and Economics, Italy

Removing the major allergen to tackle food allergies.
( Assou et al., 2021 )

SDN1
CRISPR/Cas

Leibniz Universität Hannover
Technische Universität Braunschweig, Germany

Reduced glucosinolate levels. Glucosinolates are anti-nutrients that can cause reduced performance and impairment of kidney and liver functions of livestock.
( Hölzl et al., 2022 )

SDN1
CRISPR/Cas

University of Bonn
Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Germany

Modified composition: accumulation of fivefold more starch than WT leaves, and more sucrose as well. Architectural changes
(Bezrutczyk et al., 2018)

SDN1
CRISPR/Cas

Heinrich Heine University Düsseldorf
Max Planck Institute for Plant Breeding Research, Germany
Department of Plant Biology, Carnegie Science, USA

Important metabolic changes affecting tomato fruit quality. Reduced contents of the anti-nutrient oxalic acid.
( Gago et al., 2017 )

SDN1
ZFN

University of Algarve, Portugal
Centre for Research and Technology Hellas
Technological Educational Institution of Crete, Greece

Reduce allergen proteins. Structural and metabolic proteins, like α-amylase/trypsin inhibitors are involved in the onset of wheat allergies (bakers' asthma) and probably Non-Coeliac Wheat Sensitivity (NCWS).
( Camerlengo et al., 2020 )

SDN1
CRISPR/Cas

University of Tuscia, Italy
Rothamsted Research, UK
Impasse Thérèse Bertrand-Fontaine, France

Glossy sheat phenotype.
( Gerasimova et al., 2023 )

SDN1
CRISPR/Cas

Siberian Branch of the Russian Academy of Sciences
Vavilov Institute of Plant Genetic Resources (VIR)
Siberian Branch of the Russian Academy of Sciences, Russia

Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Germany

Starch with an increased amylose ratio and elongated amylopectin chains. In food products, high amylose content and long amylopectin chains contribute to a low glycaemic index (GI) after intake, playing a role in health benefits.
( Zhao et al., 2021 )

SDN1
CRISPR/Cas

Swedish University of Agricultural Sciences, Sweden
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Laboratorio de Agrobiotecnología (INTA), Argentina

Altered gliadin levels resulting in improved end-use quality and reduced gluten epitopes associated with celiac disease. Gliadins are important for wheat end-use traits.
( Liu et al., 2023 )

SDN1
CRISPR/Cas

China Agricultural University, China
Research Centre for Cereal and Industrial Crops, Italy

Traits related to increased plant yield and growth

Increased seed oil content (SOC). SOC is a major determinant of yield and quality.
( Karunarathna et al., 2020 )

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel, Germany
Zhejiang University, China

Improved spikelet number per panicle led to increased grain yield per plant.
( Ludwig et al., 2023 )

SDN1
CRISPR/Cas

International Rice Research Institute (IRRI), Philippines
University of Pavia, Italy

Control meristem size to increase fruit yield.
( Yuste-Lisbona et al., 2020 )

SDN1
CRISPR/Cas

Universidad de Almería
Universitat Politècnica de València–Consejo Superior de Investigaciones Científicas
Spain
Max Planck Institute for Plant Breeding Research
Thünen Institute of Forest Genetics, Germany
Université Paris-Saclay, France

Increased water use efficiency without growth reductions in well-watered conditions.
( Blankenagel et al., 2022 )

SDN1
CRISPR/Cas

Technical University of Munich
Max Planck Institute of Molecular Plant Physiology
German Research Center for Environmental Health
KWS SAAT SE &
Co.KGaA
Université Technique de Munich
Heinrich Heine University, Germany
LEPSE - Écophysiologie des Plantes sous Stress environnementaux, France

Early flowering. Day-light sensitivity limited the geographical range of cultivation.
( Soyk et al., 2016 )

SDN1
CRISPR/Cas

Cold Spring Harbor Laboratory, USA
Max Planck Institute for Plant Breeding Research, Germany
Université Paris-Scalay, France

Altered spike architecture.
( de Souza Moraes et al., 2022 )

SDN1
CRISPR/Cas

Wageningen University and Research, The Netherlands
Universidade de São Paulo, Brazil
Norwich Research Park, UK
Rheinische Friedrich-Wilhelms-Universität, Germany

Root growth angle regulation, among the most important determinants of root system architecture. Root growth angle controls water uptake capacity, stress resilience, nutrient use efficiency and thus yield of crop plants.
( Kirschner et al., 2021 )

SDN1
CRISPR/Cas

University of Bonn
University of Cologne
Leibniz Institute of Plant Genetics and Crop Plant Research Gatersleben
Justus-Liebig-University Giessen, Germany
University of Bologna, Italy

Control grain size and seed coat color.
( Tra et al., 2021 )

International Rice Research Institute, Philippines
Dahlem Center of Plant Sciences Freie UniversitÃ¤t, Germany
Synthetic Biology, Biofuel and Genome Editing R&
D Reliance Industries Ltd, India

Increased water use efficiency, a promising approach for achieving sustainable crop production in changing climate scenarios.
( Blankenagel et al., 2022 )

SDN1
CRISPR/Cas

Technical University of Munich
Max Planck Institute of Molecular Plant Physiology
Helmholtz Center Munich
Heinrich Heine University Düsseldorf, Germany

Induced erect leaf habit and shoot growth for a more efficient light penetration into lower canopy layers.
( Fladung et al., 2021 )

SDN1
CRISPR/Cas

Thünen Institute of Forest Genetics, Germany

Increased shatter resistance to avoid seed loss during mechanical harvest.
( Braatz et al., 2017 )

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel, Germany

Increased yield: plants produced more tillers and grains than azygous wild-type controls and the total yield was increased up to 15 per cent.
(Holubova et al., 2018)

SDN1
CRISPR/Cas

Palacký University
Centre of the Region Haná for Biotechnological and Agricultural Research, Czech Republic
Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Germany

Combine agronomically desirable traits with useful traits present in wild lines. Threefold increase in fruit size and a tenfold increase in fruit number. Fruit lycopene accumulation is improved by 500% compared with the widely cultivated S. lycopersicum.
( Zsögön et al., 2018 )

SDN1
CRISPR/Cas

Universidade Federal de Viçosa
Universidade de São Paulo Paulo, Brazil
University of Minnesota, USA
Universität Münster, Germany

Traits related to industrial utilization

Conversion of hulled into naked barley.
( Gasparis et al., 2018 )

SDN1
CRISPR/Cas

National Research Institute
Warsaw University of Life Sciences (SGGW), Poland

Removal of methyl iodide emissions. The release of methyl iodide in the athmospere causes ozone depletion and thus represents an important environmental threat.
( Carlessi et al., 2021 )

SDN1
CRISPR/Cas

PlantLab
Institute of Life Sciences
Scuola Superiore Sant’Anna
University of Pisa
University of Milan, Italy

Nicotine-free tobacco.
( Schachtsiek et al., 2019 )

SDN1
CRISPR/Cas

TU Dortmund University, Germany

Pollen Self-Elimination, which prevents pollen transgene dispersal.
( Wang et al., 2023 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences (CAAS)
Northwest A&
F University
Hainan Yazhou Bay Seed Lab
Henan Jinyuan Seed Industry Co., China
International Maize and Wheat Improvement Center (CIMMYT), Mexico

Accelerated domestication of African rice landraces by improving domestication traits such as sheed shattering, lodging and seed yield. The acceleration of the development of high-yield African landrace varieties is important considering that Africa has a strong growing population and prone to food shortage.
( Lacchini et al., 2020 )

SDN1
CRISPR/Cas

University of Milan, Italy
University of Montpellier, France

Traits related to product color/flavour

Colour shift. The poinsettia belongs to most economically important potted ornamental plants. Customers are willing to pay higher prices for unusual varieties.
( Nitarska et al., 2021 )

SDN1
CRISPR/Cas

Technische Universität Wien, Austria
Klemm+Sohn GmbH &
Co
Leibniz Universität Hannover, Germany

Increased content of phenylacetaldehyde, sucrose and fructose, which are major contributors to flavor in many foods, including tomato.
( Li et al., 2023 )

SDN1
CRISPR/Cas

University of Florida, USA
Max-Planck-Institute of Molecular Plant Physiology, Germany

Anthocyanin-rich and pigmented sweet oranges.
( Salonia et al., 2022 )

SDN1
CRISPR/Cas

Research Centre for Olive Fruit and Citrus Crops
University of Catania
Research and Innovation Centre Trento, Italy

Color modification due to reduced anthocyanin accumulation.
( Klimek-Chodacka et al., 2018 )

SDN1
CRISPR/Cas

University of Agriculture in Krakow, Poland
East Carolina University
University of Maryland, USA

Traits related to storage performance

Reduced fruit flesh browning. The browning of eggplant berry flesh after cutting has a negative impact on fruit quality for both industrial transformation and fresh consumption.
( Maioli et al., 2020 )

SDN1
CRISPR/Cas

University of Torino, Italy
Instituto de Biologica Molecular y Celular de Plantas (IBMCP)
Universitat Politècnica de València, Spain

Reduced enzymatic browning. The formation of dark-colored precipitates in fruits and vegetables causes undesirable changes in organoleptic properties and the loss of nutritional quality.
( Gonzalez et al., 2020 )

SDN1
CRISPR/Cas

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Laboratorio de Agrobiotecnología (INTA)
Universidad Nacional de Mar del Plata, Argentina
Swedish University of Agricultural Sciences, Sweden

Traits categories

Genome Editing Technique

Countries

Plant

Sdn Type

Traits related to biotic stress tolerance

Traits related to abiotic stress tolerance

Traits related to improved food/feed quality

Traits related to increased plant yield and growth

Traits related to industrial utilization

Traits related to product color/flavour

Traits related to storage performance