genome search | EU-SAGE

Genome-editing techniques are promising tools in plant breeding. To facilitate a more comprehensive understanding of the use of genome editing, EU-SAGE developed an interactive, publicly accessible online database of genome-edited crop plants as described in peer-reviewed scientific publications.
The aim of the database is to inform interested stakeholder communities in a transparent manner about the latest evidence about the use of genome editing in crop plants. Different elements including the plant species, traits, techniques, and applications can be filtered in this database.
Regarding the methodology, a literature search in the bibliographic databases and web pages of governmental agencies was conducted using predefined queries in English. Identifying research articles in other languages was not possible due to language barriers. Patents were not screened.
Peer-reviewed articles were screened for relevance and were included in the database based on pre-defined criteria. The main criterium is that the research article should describe a research study of any crop plant in which a trait has been introduced that is relevant from an agricultural and/or food/feed perspective. The database does neither give information on the stage of development of the crop plant, nor on the existence of the intention to develop the described crop plants to be marketed.
This database will be regularly updated. Please contact us via the following webpage in case you would like to inform us about a new scientific study of crops developed for market-oriented agricultural production as a result of genome editing

Displaying 53 results

Traits related to biotic stress tolerance

Fungal resistance: increased resistance to southern leaf blight (SLB), caused by the necrotrophic fungal pathogen Cochliobolus heterostrophus (anamorph Bipolaris maydis). SLB is a major foliar disease which causes significant yield losses in maize worldwide.
(Chen et al., 2023)

SDN1
CRISPR/Cas

Northwest A&
F University, China
Corteva AgriscienceTM
USDA-ARS
North Carolina State University, USA

Bacterial resistance: Resistance against African Xanthomonas oryzae isolates, causing agents of bacterial blight. Bacterial blight threatens rice populations in Asia and West Africa.
(Li et al., 2024)

University of Missouri
Donald Danforth Plant Science Center, USA
Department of Nanjing Agricultural University, China

Bacterial resistance: Strong resistance to Xanthomonas oryzae, causing bacterial blight, a devastating rice disease resulting in yield losses.
(Li et al., 2012)

SDN1
TALENs

Iowa State University, USA

Bacterial resistance: Enhanced resistance against hemibiotrophic pathogens M. oryzae and Xanthomonas oryzae pv. oryzae (but increased susceptibility to Cochliobolus miyabeanus)
(Kim et al., 2022)

SDN1
CRISPR/Cas

Seoul National University
Kyung Hee University, South Korea
Pennsylvania State University, USA

Fungal resistance: Decreased susceptibility against sheath blight disease caused by Rhizoctonia solani AGI-1A and is one of the three major rice diseases. Sheath blight disease can cause severe yield losses.
(Zhao et al., 2024)

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences
Hebei Agricultural University
Agricultural College of Yangzhou University, China
The Ohio State University, USA

Bacterial resistance: Strong resistance to Xanthomonas oryzae, causing bacterial blight, a devastating rice disease resulting in yield losses.
(Zhou et al., 2015)

SDN1
CRISPR/Cas

Iowa State University, USA

Viral resistance: increased resistance to turnip mosaic virus (TuMV).
(Lee et al., 2023)

SDN1
CRISPR/Cas

Rural Development Administration
Advanced Institute for Science and Technology, South Korea
North Carolina State University, USA

Bacterial resistance: Strong resistance to Xanthomonas oryzae, causing bacterial blight, a devastating rice disease resulting in yield losses.
(Shan et al., 2013)

SDN1
TALENs

Chinese Academy of Sciences, University of Electronic Science and Technology of China, China
University of Minnesota, USA

Broad-spectrum disease resistance without yield loss.
( Sha et al., 2023 )

SDN1
CRISPR/Cas

Huazhong Agricultural University
Chengdu Normal University
Jiangxi Academy of Agricultural Sciences
Anhui Agricultural University
BGI-Shenzhen
Northwest A&
F University
Shandong Academy of Agricultural Sciences, China
Université de Bordeaux, France
University of California
The Joint BioEnergy Institute, USA
University of Adelaide, Australia

Bacterial resistance: improved resistance to Xanthomonas oryzae, which causes bacterial blight, a devastating rice disease resulting in yield losses.
(Oliva et al., 2019)

SDN1
CRISPR/Cas

International Rice Research Institute, Philippines
University of Missouri
University of Florida
Iowa State University
Donald Danforth Plant Science Center, USA
Université Montpellier, France
Heinrich Heine Universität Düsseldorf
Max Planck Institute for Plant Breeding Research
Erfurt University of Applied Sciences, Germany
Nagoya University, Japan

Bacterial resistance: Strong resistance to Xanthomonas oryzae, causing bacterial blight, a devastating rice disease resulting in yield losses.
(Li et al., 2013)

SDN1
TALENs

Iowa State University, USA
Guangxi University, China

Traits related to abiotic stress tolerance

Improved salinity tolerance.
( Wang et al., 2022 )

SDN1
CRISPR/Cas

National Taiwan University, Taiwan
University of North Carolina, USA

Traits related to improved food/feed quality

Carotenoid-enriched. Carotenoids, the source of pro vitamin A, are an essential component of dietary antioxidants.
( Dong et al., 2020 )

SDN3
CRISPR/Cas

University of California
Innovative Genomics Institute
The Joint Bioenergy Institute, USA

Alteration of the inositol phosphate profile in developing seeds.
( Shukla et al., 2009 )

SDN1
ZFN

Dow AgroSciences
Sangamo BioSciences, USA

Increased RS. Cereals high in RS may be beneficial to improve human health and reduce the risk of diet-related chronic diseases.
( Biswas et al., 2022 )

SDN1
CRISPR/Cas

Texas A&
M Univ.
Avance Biosciences Inc., USA

Glossy phenotype. Reduced epicuticular wax in leaves.
( Char et al., 2015 )

SDN1
TALENs

Iowa State University, USA

Modified composition: accumulation of fivefold more starch than WT leaves, and more sucrose as well. Architectural changes
(Bezrutczyk et al., 2018)

SDN1
CRISPR/Cas

Heinrich Heine University Düsseldorf
Max Planck Institute for Plant Breeding Research, Germany
Department of Plant Biology, Carnegie Science, USA

Increased amylose content. Cereals high in amylose content (AC) and resistant starch (RS) offer potential health benefits and reduce risks of diseases such as coronary heart disease, diabetes and certain colon and rectum cancers.
( Sun et al., 2017 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences, China
University of California, USA
University of Liege, Belgium

Increased lysine content with recovered kernel hardness. Lysine is considered of great nutritional importance in animal feeds and human foods.
( Hurst et al., 2023 )

SDN1
CRISPR/Cas

University of Nebraska-Lincoln
Center for Plant Science Innovation
University of Missouri-Columbia, USA

High-quality sugar production by rice (98% sucrose content). Carbohydrates are an essential energy-source. Sugarcane and sugar beet were the only two crop plants used to produce sugar.
( Honma et al., 2020 )

SDN1
CRISPR/Cas

Fujian Agriculture and Forestry University, China
Faculty of Engineering
Kitami Institute of Technology
NagoyaUniversity
Tokyo Metropolitan University, Japan
Carnegie Institution for Science, USA

Improve glutinosity in elite varieties. Decreased amylose content without affecting other desirable agronomic traits.
( Zhang et al., 2018 )

SDN1
CRISPR/Cas

Chinese Academy of Sciences, China
Purdue University
University of Queensland, USA

Increased grain weight and grain size. Carbohydrate and total protein levels also increased.
( Guo et al., 2021 )

SDN1
CRISPR/Cas

Sichuan Agricultural University, China
University of California, USA

Reduced phytate production + herbicide tolerance. Generation of a dual phenotype through targeted manipulation of a single locus.
( Shukla et al., 2009 )

SDN3
ZFN

Dow AgroScience, USA

Reduced grain chalkiness.
( Gann et al., 2023 )

SDN1
CRISPR/Cas

Cell and Molecular Biology Program
Department of Chemistry and Biochemistry
University of Arkansas at Little Rock, USA

Traits related to increased plant yield and growth

Early flowering under long day conditions of higher latitudes to spread production of maize over a broad range of latitudes rapidly.
( Huang et al., 2018 )

SDN1
CRISPR/Cas

University of Wisconsin, USA

Increased yield.
( Zhou et al., 2019 )

SDN1
CRISPR/Cas

University of Electronic Science and Technology of China
Xichang University, China
University of Maryland, USA

Enhanced photosynthesis.
( Caddell et al., 2023 )

SDN1
CRISPR/Cas

United States Department of Agriculture - Agricultural Research Service (USDA ARS)
University of California at Berkeley
Utah State University
Texas A&
M University, USA

Enhancing grain-yield-related traits by increases in meristem size
( Liu et al., 2021 )

SDN1
CRISPR/Cas

Cold Spring Harbor
University of Massachusetts Amherst, USA

Increased grain yield under field drought stress conditions and no yield loss under well-watered conditions.
( Shi et al., 2017 )

SDN1
CRISPR/Cas

DuPont Pioneer, USA

Increased bending strength. Stalk lodging, which is generally determined by stalk strength, results in considerable yield loss and has become a primary threat to maize yield under high-density planting.
( Zhang et al., 2020 )

SDN1
CRISPR/Cas

China Agricultural University, China
Iowa State University, USA

Haploid induction to accelerate breeding in crop plants.
( Kelliher et al., 2017 )

SDN1
TALENs

Syngenta Seeds, USA

Increased total kernel number or kernel weight.
( Kelliher et al., 2019 )

SDN1
CRISPR/Cas

Research Triangle Park
University of Georgia, USA
Syngenta Crop Protection, The Netherlands

Increased plant yield due to architectural changes. Leaf inclination: maize plants with upright leaves can be planted at higher densities without shading.
(Brekke et al., 2011)

SDN1
CRISPR/Cas

Iowa State University, USA

Early flowering and maturity. Flowering time (heading date) is an important trait for crop yield and cultivation.
( Wang et al., 2020 )

SDN1
CRISPR/Cas

Sinobioway Bio-Agriculture Group, Co., China
Corteva™ Agriscience, USA

Increased grain size and modulated shoot architecture.
( Miao et al., 2020 )

SDN1
CRISPR/Cas

Zhejiang A&
F University
Nanchang University
Chinese Academy of Sciences, China
Purdue University, USA

Improved nitrogen use efficiency.
( Li et al., 2018 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences
Huazhong Agricultural University, China
University of California, USA

Increased yield under different environmental conditions: well-watered, drought, normal nitrogen and low nitrogen field conditions and at multiple geographical locations.
(Wang et al., 2020)

SDN1
CRISPR/Cas

Sinobioway Bio-Agriculture Group Co.
Ltd
Corteva Agriscience
Johnston, USA

Promoted rice growth and productivity.
( Miao et al., 2018 )

SDN1
CRISPR/Cas

Chinese Academy of Sciences, China
Purdue University, USA

Improved field performance: higher yield, producing on average 5.5 bushels per acre more. Waxy corn.
(Gao et al., 2020)

SDN1
CRISPR/Cas

Corteva Agriscience, USA

Traits related to industrial utilization

Generating male sterility lines (MLS). Using MLS in hybrid seed production for monoclinous crops reduces costs and ensures high purity of the varieties because it does not produce pollen and has exserted stigmas.
( Svitashev et al., 2015 )

SDN1
CRISPR/Cas

DuPont Pioneer, USA

Enhanced biological nitrogen fixation to reduce the use of inorganic nitrogen fertilizers. Enhanced biofilm formation of soil diazotrophic bacteria by modified root microbiome structure.
( Yan et al., 2022 )

SDN1
CRISPR/Cas

University of California
Bayer Crop Science, USA

Asexual propagation trough seeds. Induction of apomeiosis, mitosis instead of meiosis. This proces leads to the production of genetically identical seeds, serving many applications in plant breeding.
( Khanday et al., 2019 )

SDN1
CRISPR/Cas

University of California
Innovative Genomics Institute
Iowa State University, USA
Université Paris-Saclay, France

Induction of haploid plants and a reduced seed set for rice breeding.
( Yao et al., 2018 )

SDN2
CRISPR/Cas

ZhongGuanCun Life Science Park, China
Syngenta India Limited
Technology Centre
Medchal Mandal, India
Syngenta Crop Protection
LLC
Research Triangle Park, USA

Trait stacking. Modern agriculture demands crops carrying multiple traits.
( Ainley et al., 2013 )

SDN1
ZFN

Dow AgroSciences LLC
Sangamo BioSciences, Inc., USA

Male sterility.
( Djukanovic et al., 2013 )

I-CreI

DuPont/Pioneer Agricultural Biotechnology
Precision Biosciences, USA

Traits related to herbicide tolerance

Imidazolinone & sulfonylurea
( Zhu et al., 1999 )

ODM

Pioneer Hi-Bred International, USA

Herbicide resistance.
( Li et al., 2016 )

SDN2
TALENs

Iowa State University, USA

Chlorsulfuron
( Svitashev et al., 2016 )

SDN1
CRISPR/Cas

DuPont Pioneer, USA

Resistance to either imidazolinone or sulfonylurea herbicides
( Zhu et al., 1999 )

ODM

Pioneer Hi-Bred International, USA

Chlorsulfuron
( Svitashev et al., 2015 )

SDN2
CRISPR/Cas

DuPont Pioneer, USA

Bialaphos & quizalofop.
( Shukla et al., 2009 )

SDN3
ZFN

Dow AgroSciences
Sangamo BioSciences, USA

Bispyribac sodium
( Butt et al., 2017 )

SDN2
CRISPR/Cas

King Abdullah University of Science and Technology, Saudi Arabia
Agricultural Research Center, Egypt
Rice University, USA

Resistance to imidazolinone herbicides.
( Zhu et al., 2000 )

ODM

Novartis Agricultural Discovery Institute
Pioneer Hi-Bred International, USA

Traits categories

Genome Editing Technique

Countries

Plant

Sdn Type

Traits related to biotic stress tolerance

Traits related to abiotic stress tolerance

Traits related to improved food/feed quality

Traits related to increased plant yield and growth

Traits related to industrial utilization

Traits related to herbicide tolerance