genome search | EU-SAGE

Genome-editing techniques are promising tools in plant breeding. To facilitate a more comprehensive understanding of the use of genome editing, EU-SAGE developed an interactive, publicly accessible online database of genome-edited crop plants as described in peer-reviewed scientific publications.
The aim of the database is to inform interested stakeholder communities in a transparent manner about the latest evidence about the use of genome editing in crop plants. Different elements including the plant species, traits, techniques, and applications can be filtered in this database.
Regarding the methodology, a literature search in the bibliographic databases and web pages of governmental agencies was conducted using predefined queries in English. Identifying research articles in other languages was not possible due to language barriers. Patents were not screened.
Peer-reviewed articles were screened for relevance and were included in the database based on pre-defined criteria. The main criterium is that the research article should describe a research study of any crop plant in which a trait has been introduced that is relevant from an agricultural and/or food/feed perspective. The database does neither give information on the stage of development of the crop plant, nor on the existence of the intention to develop the described crop plants to be marketed.
This database will be regularly updated. Please contact us via the following webpage in case you would like to inform us about a new scientific study of crops developed for market-oriented agricultural production as a result of genome editing

Displaying 46 results

Traits related to biotic stress tolerance

Mutants were compromised in infectivity of Phytophthora palmivora, a destructive oomycete plant pathogen with a wide host range
( Pettongkhao et al., 2022 )

SDN1
CRISPR/Cas

Prince of Songkla University, Thailand
University of Hawaii at Manoa
East-West Center, USA
Sainsbury Laboratory Cambridge University (SLCU), UK

Viral resistance: increased control on viral pathogen Banana streak virus (BSV). The BSV integrates in the banana host genome as endogenous BSV (eBSV). When banana plants are stressed, the eBSV produces infectious viral particles and thus the plant develops disease symptoms.
(Tripathi et al., 2019)

SDN1
CRISPR/Cas

International Institute of Tropical Agriculture (IITA), Kenya
University of California, USA

Viral resistance: reduced viral accumulation and amelioration of virus-induced symptoms by Potato Virus Y.
(Lucioli et al., 2022)

SDN1
CRISPR/Cas

ENEA
Council for Agricultural Research and Economics (CREA), Italy
National Agricultural Research and Innovation Centre, Hungary

Enhanced resistance to insects, no serotonin production and higher salicylic acid levels. Rice brown planthopper (BPH; Nilaparvata lugens Stål) and striped stem borer (SSB; Chilo suppressalis) are the two most serious pests in rice production.
( Lu et al., 2018 )

SDN1
CRISPR/Cas

Zhejiang University
Jiaxing Academy of Agricultural Sciences
Wuxi Hupper Bioseed Ltd.
Hubei Collaborative Innovation Center for Grain Industry, China
Newcastle University, UK

Bacterial resistance: Enhanced resistance to Xanthomonas campestris pv. musacearum, causing Bananas Xanthomonas wilt (BXW). Overall economic losses caused by Xanthomonas campestris were estimated at 2-8 billion USD over a decade.
(Tripathi et al., 2021)

SDN1
CRISPR/Cas

International Institute of Tropical Agriculture (IITA), Kenya

Fungal resistance: improved resistance to necrotrophic fungus Botrytis cinerea.
(Jeon et al., 2020)

SDN1
CRISPR/Cas

Stanford University, UK
L’Oreal, France
Howard Hughes Medical Institute, USA

Resistance to parasitic weed: Striga spp. The parasitic plant reduces yields of cereal crops worldwide.
(Hao et al., 2023)

SDN1
CRISPR/Cas

University of Nebraska-Lincoln
Pennsylvania State University, USA
International Maize and Wheat Improvement Center (CIMMYT), Senegal
Kenyatta University, Kenya

Viral resistance: partial resistance to Pepper veinal mottle virus (PVMV) isolate IC, with plants harboring weak symptoms and low virus loads at the systemic level.
(Moury et al., 2020)

SDN1
CRISPR/Cas

INRA, France
Université de Tunis El-Manar
Université de Carthage, Tunisia
Université Felix Houphouët-Boigny, Cote d’Ivoire
Institut de l’Environnement et de Recherches Agricoles, Burkina Faso

Rapid and on-site detection of the mycotoxin zearalenone.
( Pei et al., 2024 )

SDN1
CRISPR/Cas

Shaanxi University of Science and Technology
Anhui Agricultural University
China National Center for Food Safety Risk Assessment, China
Queen'
s University Belfast, UK

Fungal resistance: resistance to Oidium neolycopersici, causing powdery mildew.
(Nekrasov et al., 2017)

SDN1
CRISPR/Cas

Max Planck Institute for Developmental Biology, Germany
Norwich Research Park, UK

Viral resistance: enhanced Potato virus Y (PVY) resistance. PVY infection can result in up to 70% yield loss globally.
(Le et al., 2022)

SDN1
CRISPR/Cas

Vietnam Academy of Science and Technology, Vietnam
University of Edinburgh, UK

Viral resistance: Highly efficient resistance against wheat dwarf virus (WDV), an economically important virus. WDV infect both wheat and barley causing severe yield losses. The natural resistance resources are limited.
(Kis et al., 2019)

SDN1
CRISPR/Cas

University of Pannonia
Hungarian Academy of Sciences
Eötvös Loránd University University
Szent István University, Hungary

Bacterial resistance: resistance against banana Xanthomonas wilt (BXW) disease, caused by Xanthomonas campestris pv. musacearum. BXW forms a great threat to banana cultivation in East and Central Africa.
(Ntui et al., 2023)

SDN1
CRISPR/Cas

International Institute of Tropical Agriculture, Kenya

Traits related to abiotic stress tolerance

Higher tolerance to salt and osmotic stress through reduced stomatal conductance coupled with increased leaf relative water content and Abscisic acid (ABA) content under normal and stressful conditions.
( Bouzroud et al., 2020 )

SDN1
CRISPR/Cas

Université Mohammed V de Rabat, Morocco
Université de Toulouse, France
Universidade Federal de Viçosa, Brazil

Drought tolerance.
( Njuguna et al., 2018 )

SDN1
CRISPR/Cas

Ghent University
Center for Plant Systems Biology, Belgium
Jomo Kenyatta University of Agriculture and Technology, Kenya

Traits related to improved food/feed quality

Increased iron (Fe) and magnesium (Mn) content for biofortification: increasing the intrinsic nutritional value of crops.
(Connorton et al., 2017)

SDN1
CRISPR/Cas

John Innes Centre
University of East Anglia, UK

Production of opaque seeds with depleted starch reserves. Reduced starch content and increased amylose content. Accumulation of multiple sugars, fatty acids, amino acids and phytosterols.
( Baysal et al., 2020 )

SDN1
CRISPR/Cas

University of Lleida-Agrotecnio Center
Catalan Institute for Research and Advanced Studies (ICREA), Spain
Royal Holloway University of London, UK

Enhancing the accumulation of eicosapentaenoic acid and docosahexaenoic acid, essential components of a healthy, balanced diet.
( Han et al., 2022 )

SDN1
CRISPR/Cas

Rothamsted Research, UK
Montana State University, USA

Reduced accumulation of free asparagine, the precursor for acrylamide. Acrylamide is a contaminant which forms during the baking, toasting and high-temperature processing of foods made from wheat.
( Raffan et al., 2021 )

SDN1
CRISPR/Cas

Rothamsted Research
University of Bristol, UK

Changing grain composition: decrease in the prolamines, an increase in the glutenins, increased starch content, amylose content, and β-glucan content. The protein matrix surrounding the starch granules was increased.
(Yang et al., 2020)

SDN1
CRISPR/Cas

Sichuan Agricultural University, China
Norwich Research Park, UK
CSIRO Agriculture and Food, Australia

Reduce allergen proteins. Structural and metabolic proteins, like α-amylase/trypsin inhibitors are involved in the onset of wheat allergies (bakers' asthma) and probably Non-Coeliac Wheat Sensitivity (NCWS).
( Camerlengo et al., 2020 )

SDN1
CRISPR/Cas

University of Tuscia, Italy
Rothamsted Research, UK
Impasse Thérèse Bertrand-Fontaine, France

Altered starch properties. Changes in amylopectin chain-lengths, starch granule initiation and branching frequency.
( Tuncel et al., 2019 )

SDN1
CRISPR/Cas

Norwich Research Park, UK

Increased grain number per spikelet.
( Zhang et al., 2019 )

SDN1
CRISPR/Cas

University of Missouri
South Dakota State University
University of California
Donald Danforth Plant Science Center, USA
University of Bristol, UK

Specific differences in grain morphology, composition and (1,3;1,4)-β-glucan content. Barley rich in (1,3;1,4)-β-glucan, a source of fermentable dietary fibre, is useful to protect against various human health conditions. However, low grain (1,3;1,4)-β-glucan content is preferred for brewing and distilling.
( Garcia-Gimenez et al., 2020 )

SDN1
CRISPR/Cas

The James Hutton Institute
University of Dundee, UK
University of Adelaide
La Trobe University, Australia

Traits related to increased plant yield and growth

Altered spike architecture.
( de Souza Moraes et al., 2022 )

SDN1
CRISPR/Cas

Wageningen University and Research, The Netherlands
Universidade de São Paulo, Brazil
Norwich Research Park, UK
Rheinische Friedrich-Wilhelms-Universität, Germany

Promote growth of axillary buds. Lateral branches develop from the axillary buds. The number of side branches is very important to plant architecture, which influences the yield and quality of the plant.
( Li et al., 2021 )

SDN1
CRISPR/Cas

Guizhou University
Northwest A&
F University
Shandong Agricultural University
Northeast Agricultural University
Shanxi University, China
Oxford University
University of Bedfordshire, UK

Regulated sepal growth
( Xing et al., 2022 )

SDN1
CRISPR/Cas

China Agricultural University
Chinese Academy of Sciences
Zhejiang University, China
University of Nottingham, UK

Dwarf phenotype.
( Lawrenson et al., 2015 )

SDN1
CRISPR/Cas

Norwich Research Park, UK
Murdoch University, USA

Dwarf phenotype. Tomatoes with compact growth habits and reduced plant height can be useful in some environments.
( Tomlinson et al., 2019 )

SDN1
CRISPR/Cas

Norwich Research Park, UK
University of Minnesota, USA

Early flowering phenotype with no adverse effect on yield.
( Shang et al., 2023 )

SDN1
CRISPR/Cas

Huazhong Agricultural University
Hubei Hongshan Laboratory
Chinese Academy of Agricultural Sciences, China
University of Nottingham, UK

Positive regulation for grain dormancy. Lack of grain dormancy in cereal crops causes losses in yield and quality because of preharvest sprouting.
( Lawrenson et al., 2015 )

SDN1
CRISPR/Cas

Norwich Research Park, UK
Murdoch University, Australia

Traits related to industrial utilization

New red-grained and pre-harvest sprouting (PHS)-resistant wheat varieties with elite agronomic traits. PHS reduces yield and grain quality, additionally the red pigment of the grain coat contains proanthocyanidins, which have antioxidant activity and thus health-promoting properties.
( Zhu et al., 2022 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences
Fujian Academy of Agricultural Sciences
Henan University
Shenzhen Research Institute of Henan university
Taiyuan University of Technology
Southern University of Science and Technology, China
University of Edinburgh, UK

Conferring water logging tolerance for further expansion of the cultivation area.
( Abdullah et al., 2021 )

SDN1
CRISPR/Cas

Faculty of Agriculture
University of Nottingham
Universiti Putra Malaysia, Malaysia

Hairy root transformation. Hairy roots play a role in multiple processes, ranging from recombinant protein production and metabolic engineering to analyses of rhizosphere physiology and biochemistry.
( Ron et al., 2014 )

SDN1
CRISPR/Cas

University of California
Emory University, USA
University of Cambridge, UK

Traits related to product color/flavour

Improved aroma, flavour and fatty acid (FA) profiles of pea seeds.
( Bhowmik et al., 2023 )

SDN1
CRISPR/Cas

National Research Council Canada (NRC)
University of Calgary
University of Saskatchewan
Agriculture and Agri-Food Canada (AAFC)
St. Boniface Hospital Research, Canada
John Innes Centre, UK

Albino phenotype.
( Yeap et al., 2021 )

SDN1
CRISPR/Cas

Sime Darby Plantation Technology Centre Sdn. Bhd.
Sime Darby Plantation Research Sdn. Bhd., Malaysia

Albino phenotype.
( Wilson et al., 2019 )

SDN1
CRISPR/Cas

NIAB EMR, UK

Albino phenotype.
( Syombua et al., 2021 )

SDN1
CRISPR/Cas

International Institute of Tropical Agriculture (IITA)
University of Nairobi, Kenya
University of Missouri
Iowa State University
Donald Danforth Plant Science Center, USA

Albino phenotype
( Bánfalvi et al., 2020 )

SDN1
CRISPR/Cas

NARIC Agricultural Biotechnology Institute, Hungary

Albino phenotype.
( Wilson et al., 2019 )

SDN1
CRISPR/Cas

NIAB EMR, UK

Traits related to storage performance

Improved shelf-life with improved or not affected sugar: acid ratio, aroma volatiles, and skin color.
(Ortega-Salazar et al., 2023)

SDN1
CRISPR/Cas

University of California, USA
Zhejiang Normal University, China
University of Nottingham, UK

Extended root shelf-life, which decreases its wastage.
( Mukami et al., 2023 )

SDN1
CRISPR/Cas

Kenyatta University
Jomo Kenyatta University of Agriculture Technology
Pwani University Kilifi, Kenya

Improved shelf-life by targeting the genes modulating pectin degradation in ripening tomato.
( Wang et al., 2019 )

SDN1
CRISPR/Cas

University of London
University of Leicester
University of Nottingham
University of Leeds, UK
International Islamic University Malaysia, Malaysia
Shanxi Academy of Agricultural Sciences, China
University of California, USA

Controlling the rate of fruit softening to extend shelf life.
( Uluisik et al., 2016 )

SDN1
CRISPR/Cas

University of Nottingham
Royal Holloway University of London
Heygates Ltd
Syngenta Seeds
Sutton Bonington Campus, UK
Syngenta Crop Protection
University of California
Cornell University
Skidmore College, USA

Decreased postharvest water loss with a 17–30% increase in wax accumulation.
( Chen et al., 2023 )

SDN1
CRISPR/Cas

China Agricultural University
Chinese Academy of Sciences, China
University of Nottingham, UK

Altering tomato fruit ripening and softening, key traits for fleshy fruit. During ripening, fruit will gradually soften which is largely the result of fruit cell wall degradation. Softening may improve the edible quality of fruit but also reduces fruit resistance to pathogenic microorganisms. Fruit softening can cause mechanical damage during storage and transportation as well, which can reduce the storage and shelf life, leading to fruit loss.
( Gao et al., 2021 )

SDN1
CRISPR/Cas

China Agricultural University
South China Agricultural University
Fujian Agriculture and Forestry University
Zhejiang University
Beijing University of Agriculture, China
University of Nottingham, UK

Traits categories

Genome Editing Technique

Countries

Plant

Sdn Type

Traits related to biotic stress tolerance

Traits related to abiotic stress tolerance

Traits related to improved food/feed quality

Traits related to increased plant yield and growth

Traits related to industrial utilization

Traits related to product color/flavour

Traits related to storage performance