genome search | EU-SAGE

Genome-editing techniques are promising tools in plant breeding. To facilitate a more comprehensive understanding of the use of genome editing, EU-SAGE developed an interactive, publicly accessible online database of genome-edited crop plants as described in peer-reviewed scientific publications.
The aim of the database is to inform interested stakeholder communities in a transparent manner about the latest evidence about the use of genome editing in crop plants. Different elements including the plant species, traits, techniques, and applications can be filtered in this database.
Regarding the methodology, a literature search in the bibliographic databases and web pages of governmental agencies was conducted using predefined queries in English. Identifying research articles in other languages was not possible due to language barriers. Patents were not screened.
Peer-reviewed articles were screened for relevance and were included in the database based on pre-defined criteria. The main criterium is that the research article should describe a research study of any crop plant in which a trait has been introduced that is relevant from an agricultural and/or food/feed perspective. The database does neither give information on the stage of development of the crop plant, nor on the existence of the intention to develop the described crop plants to be marketed.
This database will be regularly updated. Please contact us via the following webpage in case you would like to inform us about a new scientific study of crops developed for market-oriented agricultural production as a result of genome editing

Displaying 47 results

Traits related to biotic stress tolerance

Viral resistance: Attenuated infection symptoms and reduced viral RNA accumulation, specific for the cucumber mosaic virus (CMV) or tobacco mosaic virus (TMV).
(Zhang et al., 2018)

SDN1
CRISPR/Cas

South China Agricultural University, China
University of Missouri, USA

Fungal resistance: increased resistance to southern leaf blight (SLB), caused by the necrotrophic fungal pathogen Cochliobolus heterostrophus (anamorph Bipolaris maydis). SLB is a major foliar disease which causes significant yield losses in maize worldwide.
(Chen et al., 2023)

SDN1
CRISPR/Cas

Northwest A&
F University, China
Corteva AgriscienceTM
USDA-ARS
North Carolina State University, USA

Viral resistance: increased resistance against Tobacco Mosaic Virus (TMV).
(Jogam et al., 2023)

SDN1
CRISPR/Cas

Kakatiya University
Center of Innovative and Applied Bioprocessing (DBT-CIAB), India
University of Minnesota
East Carolina University, USA

Viral resistance: enhanced Potato virus Y (PVY) resistance. PVY infection can result in up to 70% yield loss globally.
(Le et al., 2022)

SDN1
CRISPR/Cas

Vietnam Academy of Science and Technology, Vietnam
University of Edinburgh, UK

Viral resistance: increased resistance to infection with the potato virus Y (PVY) and tolerance to salt and osmotic stress. PVY is one of the most economically important potato pathogens
(Makhotenko et al., 2019)

SDN1
CRISPR/Cas

Russia Moscow State University, Russia
Doka Gene Technologies Ltd, USA

Traits related to abiotic stress tolerance

Increased root length, which can restore good performance under water stress.
( Gabay et al., 2023 )

SDN1
CRISPR/Cas

University of California
Howard Hughes Medical Institute, USA
University of Haifa, Israel
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Universidad Nacional de San Martín (UNSAM), Argentina
Fudan University
China Agricultural University, China
Karolinska Institutet, Sweden

Increased drought tolerance.
( Abdallah et al., 2022 )

SDN1
CRISPR/Cas

Cairo University, Egypt
Crop Improvement and Genetics Unit, USA

Drought tolerance.
( Kim D et al,. 2018 )

SDN1
CRISPR/Cas

Montana State University, USA

Traits related to improved food/feed quality

Modified composition: accumulation of fivefold more starch than WT leaves, and more sucrose as well. Architectural changes
(Bezrutczyk et al., 2018)

SDN1
CRISPR/Cas

Heinrich Heine University Düsseldorf
Max Planck Institute for Plant Breeding Research, Germany
Department of Plant Biology, Carnegie Science, USA

Reduced phytate production + herbicide tolerance. Generation of a dual phenotype through targeted manipulation of a single locus.
( Shukla et al., 2009 )

SDN3
ZFN

Dow AgroScience, USA

Increased grain number per spikelet.
( Zhang et al., 2019 )

SDN1
CRISPR/Cas

University of Missouri
South Dakota State University
University of California
Donald Danforth Plant Science Center, USA
University of Bristol, UK

Ultra-low nicotine level
( Burner et al., 2022 )

SDN1
CRISPR/Cas

North Carolina State University, USA

Alteration of the inositol phosphate profile in developing seeds.
( Shukla et al., 2009 )

SDN1
ZFN

Dow AgroSciences
Sangamo BioSciences, USA

Increased iron (Fe) and magnesium (Mn) content for biofortification: increasing the intrinsic nutritional value of crops.
(Connorton et al., 2017)

SDN1
CRISPR/Cas

John Innes Centre
University of East Anglia, UK

Amylose-free starch in tubers.
( Toinga-Villafuerte et al., 2022 )

SDN1
CRISPR/Cas

Texas A&
M University, USA

Glossy phenotype. Reduced epicuticular wax in leaves.
( Char et al., 2015 )

SDN1
TALENs

Iowa State University, USA

Reduced gluten content. Coeliac disease is an autoimmune disorder triggered in genetically predisposed individuals by the ingestion of gluten proteins.
( Sánchez-León,et al., 2017 )

SDN1
CRISPR/Cas

Instituto de Agricultura Sostenible (IASCSIC), Spain
University of Minnesota, USA

Increased lysine content with recovered kernel hardness. Lysine is considered of great nutritional importance in animal feeds and human foods.
( Hurst et al., 2023 )

SDN1
CRISPR/Cas

University of Nebraska-Lincoln
Center for Plant Science Innovation
University of Missouri-Columbia, USA

Reduced accumulation of free asparagine, the precursor for acrylamide. Acrylamide is a contaminant which forms during the baking, toasting and high-temperature processing of foods made from wheat.
( Raffan et al., 2021 )

SDN1
CRISPR/Cas

Rothamsted Research
University of Bristol, UK

Altered starch properties. Changes in amylopectin chain-lengths, starch granule initiation and branching frequency.
( Tuncel et al., 2019 )

SDN1
CRISPR/Cas

Norwich Research Park, UK

Reduce allergen proteins. Structural and metabolic proteins, like α-amylase/trypsin inhibitors are involved in the onset of wheat allergies (bakers' asthma) and probably Non-Coeliac Wheat Sensitivity (NCWS).
( Camerlengo et al., 2020 )

SDN1
CRISPR/Cas

University of Tuscia, Italy
Rothamsted Research, UK
Impasse Thérèse Bertrand-Fontaine, France

Traits related to increased plant yield and growth

Increased total kernel number or kernel weight.
( Kelliher et al., 2019 )

SDN1
CRISPR/Cas

Research Triangle Park
University of Georgia, USA
Syngenta Crop Protection, The Netherlands

Increases size of starch granules. Granule size is a key parameter for industrial processing. Larger granules may increase yield during processing and it has been shown in sweet potato that smaller starch granules degrade faster than large granules, so larger granule tubers may be beneficial for storage.
( Pfotenhauer et al., 2023 )

SDN1
CRISPR/Cas

University of Tennessee, USA

Enhancing grain-yield-related traits by increases in meristem size
( Liu et al., 2021 )

SDN1
CRISPR/Cas

Cold Spring Harbor
University of Massachusetts Amherst, USA

Increased grain weight and grain size. Carbohydrate and total protein levels also increased.
( Guo et al., 2021 )

SDN1
CRISPR/Cas

Sichuan Agricultural University, China
University of California, USA

Haploid induction to accelerate breeding in crop plants.
( Kelliher et al., 2017 )

SDN1
TALENs

Syngenta Seeds, USA

Increased bending strength. Stalk lodging, which is generally determined by stalk strength, results in considerable yield loss and has become a primary threat to maize yield under high-density planting.
( Zhang et al., 2020 )

SDN1
CRISPR/Cas

China Agricultural University, China
Iowa State University, USA

Early flowering under long day conditions of higher latitudes to spread production of maize over a broad range of latitudes rapidly.
( Huang et al., 2018 )

SDN1
CRISPR/Cas

University of Wisconsin, USA

Increased plant yield due to architectural changes. Leaf inclination: maize plants with upright leaves can be planted at higher densities without shading.
(Brekke et al., 2011)

SDN1
CRISPR/Cas

Iowa State University, USA

Increased grain yield under field drought stress conditions and no yield loss under well-watered conditions.
( Shi et al., 2017 )

SDN1
CRISPR/Cas

DuPont Pioneer, USA

Enhanced grain yield and semi-dwarf phenotype by manipulating brassinosteroid signal pathway.
( Song et al., 2023 )

SDN1
CRISPR/Cas

China Agricultural University, China
Hard Winter Wheat Genetics Research Unit, USA

Improved field performance: higher yield, producing on average 5.5 bushels per acre more. Waxy corn.
(Gao et al., 2020)

SDN1
CRISPR/Cas

Corteva Agriscience, USA

Traits related to industrial utilization

Generating male sterility lines (MLS). Using MLS in hybrid seed production for monoclinous crops reduces costs and ensures high purity of the varieties because it does not produce pollen and has exserted stigmas.
( Svitashev et al., 2015 )

SDN1
CRISPR/Cas

DuPont Pioneer, USA

Rapid generation of male sterile (MS) bread wheat. MS is an important tool in creating hybrid crop varieties that provide a yield advantage over traditional varieties by harnessing heterosis.
( Singh et al., 2021 )

SDN1
CRISPR/Cas

DuPont Pioneer, USA

Accumulate low levels of alkaloids. Nicotine is the most abundant alkaloid produced in tobacco plants. Switching to cigarettes containing levels of nicotine below the level of sustaining an addiction response will smoke less and/or find it easier to quit. Possibly, the US Food and Drug Administration (FDA) may mandate such reductions in future cigarette products.
( Smith et al., 2022 )

SDN1
CRISPR/Cas

North Carolina State University, USA

Generate self-compatible diploid potato lines for the application of efficient breeding methods.
( Enciso-Rodriguez et al., 2021 )

SDN1
CRISPR/Cas

Michigan State University, USA

New red-grained and pre-harvest sprouting (PHS)-resistant wheat varieties with elite agronomic traits. PHS reduces yield and grain quality, additionally the red pigment of the grain coat contains proanthocyanidins, which have antioxidant activity and thus health-promoting properties.
( Zhu et al., 2022 )

SDN1
CRISPR/Cas

Chinese Academy of Agricultural Sciences
Fujian Academy of Agricultural Sciences
Henan University
Shenzhen Research Institute of Henan university
Taiyuan University of Technology
Southern University of Science and Technology, China
University of Edinburgh, UK

Trait stacking. Modern agriculture demands crops carrying multiple traits.
( Ainley et al., 2013 )

SDN1
ZFN

Dow AgroSciences LLC
Sangamo BioSciences, Inc., USA

Traits related to herbicide tolerance

Imidizolinone
( Butler et al., 2016 )

SDN2
CRISPR/Cas

Michigan State University
University of Minnesota, USA

Bialaphos & quizalofop.
( Shukla et al., 2009 )

SDN3
ZFN

Dow AgroSciences
Sangamo BioSciences, USA

Chlorsulfuron
( Svitashev et al., 2015 )

SDN2
CRISPR/Cas

DuPont Pioneer, USA

Resistance to imidazolinone herbicides.
( Zhu et al., 2000 )

ODM

Novartis Agricultural Discovery Institute
Pioneer Hi-Bred International, USA

Imidazolinone & sulfonylurea
( Zhu et al., 1999 )

ODM

Pioneer Hi-Bred International, USA

Chlorsulfuron
( Svitashev et al., 2016 )

SDN1
CRISPR/Cas

DuPont Pioneer, USA

Imidizolinone
( Butler et al., 2016 )

SDN2
TALENs

Michigan State University
University of Minnesota, USA

Resistance to either imidazolinone or sulfonylurea herbicides
( Zhu et al., 1999 )

ODM

Pioneer Hi-Bred International, USA

Traits related to storage performance

Improved cold storage and processing traits: reduced levels of acrylamide, reduced sugars.
(Clasen et al., 2017)

SDN1
TALENs

Cellectis Plant Science, USA

Traits categories

Genome Editing Technique

Countries

Plant

Sdn Type

Traits related to biotic stress tolerance

Traits related to abiotic stress tolerance

Traits related to improved food/feed quality

Traits related to increased plant yield and growth

Traits related to industrial utilization

Traits related to herbicide tolerance

Traits related to storage performance