genome search | EU-SAGE

Genome-editing techniques are promising tools in plant breeding. To facilitate a more comprehensive understanding of the use of genome editing, EU-SAGE developed an interactive, publicly accessible online database of genome-edited crop plants as described in peer-reviewed scientific publications.
The aim of the database is to inform interested stakeholder communities in a transparent manner about the latest evidence about the use of genome editing in crop plants. Different elements including the plant species, traits, techniques, and applications can be filtered in this database.
Regarding the methodology, a literature search in the bibliographic databases and web pages of governmental agencies was conducted using predefined queries in English. Identifying research articles in other languages was not possible due to language barriers. Patents were not screened.
Peer-reviewed articles were screened for relevance and were included in the database based on pre-defined criteria. The main criterium is that the research article should describe a research study of any crop plant in which a trait has been introduced that is relevant from an agricultural and/or food/feed perspective. The database does neither give information on the stage of development of the crop plant, nor on the existence of the intention to develop the described crop plants to be marketed.
This database will be regularly updated. Please contact us via the following webpage in case you would like to inform us about a new scientific study of crops developed for market-oriented agricultural production as a result of genome editing

Displaying 67 results

Traits related to biotic stress tolerance

Highly significant reduction in susceptibility to fire blight, caused by the bacterium Erwinia amylovora. Apple is one of the most cultivated fruit crops throughout the temperate regions of the world.
( Pompili et al., 2020 )

SDN1
CRISPR/Cas

Università degli Studi di Udine
Fondazione Edmund Mach, Italy

Fungal resistance: effective reduction of susceptibility against downy mildew by increasing salicylic acid levels. The pathogen can devastate individual vineyards and in some cases also affect production from entire regions.
(Giacomelli et al., 2023)

SDN1
CRISPR/Cas

Research and Innovation Centre
Fondazione Edmund Mach, Italy
Enza Zaden
Hudson River Biotechnology, The Netherlands

Viral and fungal resistance: Tomato yellow leaf curl virus (TYLCV) and powdery mildew (Oidium neolycopersici), diseases which reduce tomato crop yields and cause substantial economic losses each year.
(Pramanik et al., 2021)

SDN1
CRISPR/Cas

Gyeongsang National University
Pusan National University
R&
D Center, Bunongseed Co., South Korea

Fungal resistance: enhanced resistance against powdery mildew disease.
(Xu et al., 2023)

SDN1
CRISPR/Cas

Kyungpook National University
Rural Development Administration
Sunchon National University, South Korea
Lingnan Normal University, China

Fungal resistance: increased resistance against the fungus Pyricularia oryzae, causing rice blast, one of the most destructive diseases affecting rice worldwide.
(Távora et al., 2022)

SDN1
CRISPR/Cas

Federal University of Juiz de Fora
Embrapa Genetic Resources and Biotechnology
Catholic University of Brasilia
Catholic University of Dom Bosco, Brazil
Agricultural Research Center for International Development (CIRAD)
University of Montpellier
Montpellier SupAgro, France

Viral resistance: increased resistance to turnip mosaic virus (TuMV).
(Lee et al., 2023)

SDN1
CRISPR/Cas

Rural Development Administration
Advanced Institute for Science and Technology, South Korea
North Carolina State University, USA

Oomycete resistance: resistance against downly mildew disease (DM). DM is caused by Peronospora belbahrii, a worldwide threat to the basil industry.
(Laura et al., 2023)

SDN1
CRISPR/Cas

Research Centre for Vegetable and Ornamental Crops
Institute of Agricultural Biology and Biotechnology
Institute for Sustainable Plant Protection
Research Centre for Olive Fruit and Citrus Crops
University of Pisa
Center for Agricultural Experimentation and Assistance
Institute of Biosciences and Bioresources, Italy

Bacterial resistance: enhanced resistance to Xanthomonas oryzae, causing bacterial blight, a devastating rice disease resulting in yield losses.
(Kim et al., 2019)

SDN1
CRISPR/Cas

Sejong University, South Korea

Fungal resistance: increased tolerance to Late Blight disease, which could be devastating to tomato yields.
(Maioli et al., 2024)

SDN1
CRISPR/Cas

University of Torino, Italy
Ingeniero Fausto Elio/n, Spain
Wageningen University &
Research,

Viral resistance: reduced viral accumulation and amelioration of virus-induced symptoms by Potato Virus Y.
(Lucioli et al., 2022)

SDN1
CRISPR/Cas

ENEA
Council for Agricultural Research and Economics (CREA), Italy
National Agricultural Research and Innovation Centre, Hungary

Herbicide resistance: pds (phytoene desaturase), ALS (acetolactate synthase), and EPSPS (5-Enolpyruvylshikimate-3-phosphate synthase)
(Yang et al., 2022)

SDN1
CRISPR/Cas

Chonnam National University, South Korea

Fungal and bacterial resistance: increased resistance towards the bacterial pathogen Pseudomonas syringae pv. maculicola (Psm) and fungal pathogen Alternaria brassicicola.
(Yung Cha et al., 2023)

SDN1
CRISPR/Cas

Gyeongsang National University, South Korea

Fungal resistance: increased resistance to Erysiphe necator, causing powdery mildew in grape cultivar. The pathogen infects all green tissues and berries, leading to dramatic losses in yield and berry quality.
(Malnoy et al., 2016)

SDN1
CRISPR/Cas

Fondazione Edmund Mach, Italy
ToolGen Inc.
Institute for Basic Science
Seoul National University, South Korea

Bacterial resistance: Enhanced resistance against hemibiotrophic pathogens M. oryzae and Xanthomonas oryzae pv. oryzae (but increased susceptibility to Cochliobolus miyabeanus)
(Kim et al., 2022)

SDN1
CRISPR/Cas

Seoul National University
Kyung Hee University, South Korea
Pennsylvania State University, USA

Viral resistance: resistance to pepper mottle virus (PepMoV), causing considerable damage to crop plants.
(Yoon et al., 2020)

SDN1
CRISPR/Cas

Seoul National University
National Institute of Horticultural and Herbal Science, South Korea

Bacterial resistance: Increased resistance to Erwinia amylovora, causing fire blight disease that threatens the apple and a wide range of ornamental and commercial Rosaceae host plants.
(Malnoy et al., 2016)

SDN1
CRISPR/Cas

Fondazione Edmund Mach, Italy
ToolGen Inc.
Institute for Basic Science
Seoul National University, South Korea

Fungal resistance: Enhanced resistance against powdery mildew, caused by Oidium neolycopersici, which is a major concern for the productivity of tomato plants.
(Li et al., 2024)

SDN1
CRISPR/Cas

University of Torino, Italy
Wageningen University &
Research, The Netherlands
Shanxi Agricultural University, China

Traits related to abiotic stress tolerance

Regulated circadian clock: circadian clock measures and conveys day length information to control rhythmic hypocotyl growth in photoperiodic conditions, to achieve optimal fitness. Mutants showed longer hypocotyls, lower core circadian clock morning component mRNA and protein levels, and a shorter circadian rhythm. Exposure to high temperature due to global warming.
(Kim et al., 2022)

SDN1
CRISPR/Cas

National Institute of Agricultural Science
Korea Polar Research Institute
Seoul National University College of Medicine, South Korea

Increased drought-avoidance strategy.
( Maioli et al., 2024 )

SDN1
CRISPR/Cas

University of Torino, Italy
Ingeniero Fausto Elio/n, Spain
Wageningen University &
Research, The Netherlands

Salinity tolerance. Salinity stress is one of the most important abiotic stress factors affecting rice production worldwide.
( Lim et al., 2021 )

SDN1
CRISPR/Cas

Kangwon National University
Sangji University
Kyung Hee University, South Korea

Increased drought tolerance. Plants showed lower ion leakage and higher proline content upon abiotic stress.
( Kim et al., 2023 )

SDN1
CRISPR/Cas

Chungbuk National University
Hankyong National University

Institute of Korean Prehistory, South Korea

Drought tolerance by modulating lignin accumulation in roots.
( Bang et al, 2021 )

SDN1
CRISPR/Cas

Seoul National University, South Korea

Improved drought tolerance.
( D'Incà., 2024 )

SDN1
CRISPR/Cas

University Roma Tre
Universit `a di Trieste
IOAG-BIOTECC.R. Casaccia
Sapienza University of Rome
University of Milano
Roma Tre Section
Instituto Nazionale Biostrutture e Biosistemi (INBB)
National Biodiversity Future Center, Italy

Tolerance to salt stress.
( Tran et al., 2021 )

SDN1
CRISPR/Cas

Gyeongsang National University, South Korea
College of Agriculture
Bac Lieu University, Vietnam

Cold tolerance.
( Park et al., 2023 )

SDN1
CRISPR/Cas

National Institute of Crop Science
Kyungpook National University, South Korea

Increased cuticular wax biosynthesis resulting in enhanced drought tolerance.
( Shim et al., 2023 )

SDN1
CRISPR/Cas

Seoul National University
Incheon National University
Kyung Hee University, South Korea

Higher tolerance to salt and osmotic stress through reduced stomatal conductance coupled with increased leaf relative water content and Abscisic acid (ABA) content under normal and stressful conditions.
( Bouzroud et al., 2020 )

SDN1
CRISPR/Cas

Université Mohammed V de Rabat, Morocco
Université de Toulouse, France
Universidade Federal de Viçosa, Brazil

Traits related to improved food/feed quality

Mutant cell lines doubled the accumulation level of anthocyanins biosynthesized. The production of these important pigments was stabilized over time.
( D'Amelia et al., 2022 )

SDN1
CRISPR/Cas

National Research Council of Italy
University of Naples Federico II
Council for Agricultural Research and Economics, Italy

Improvement of of functional compounds in tomato fruit, which satisfies the antioxidant properties requirements.
( Kim et al., 2024 )

SDN1
CRISPR/Cas

Hankyong National University
Chungbuk National University, South Korea

High amylose content. High-amylose starches are digested slowly which could provide increased satiety and reduced risk of diabetes, cardiovascular disease and colorectal cancer.
( Kim et al., 2023 )

SDN1
CRISPR/Cas

Kyungpook National University
National Institute of Crop Science, South Korea

Glucoraphanin(GR)-enriched broccoli. Broccoli contains important nutritional components and beneficial phytochemicals. GR, a major glucosinolate (GSL), protects the body against several chronic diseases.
( Kim et al., 2022 )

SDN1
CRISPR/Cas

Sejong University
Jeonbuk National University
Korea Research Institute of Bioscience and Biotechnology
Asia Seed Company Limited, South Korea

Reduced nicotine levels. Nicotine is the addictive component in tobacco.
( Jeong et al., 2024 )

SDN1
CRISPR/Cas

Nulla Bio Inc.
Gyeongsang National University
Gyeongsang National University 501 Jinju-daero, South Korea

Reduce allergen proteins. Structural and metabolic proteins, like α-amylase/trypsin inhibitors are involved in the onset of wheat allergies (bakers' asthma) and probably Non-Coeliac Wheat Sensitivity (NCWS).
( Camerlengo et al., 2020 )

SDN1
CRISPR/Cas

University of Tuscia, Italy
Rothamsted Research, UK
Impasse Thérèse Bertrand-Fontaine, France

Reduced phytic acid content in soybean seeds. Monogastric animals are unable to digest phytic acid, making phytic acid phosphorous in animal waste one of the major causes of environmental phosphorus pollution.
( Song et al., 2022 )

SDN1
CRISPR/Cas

Dong-A University
Korea Research Institute of Bioscience Biotechnology (KRIBB), South Korea

Altered gliadin levels resulting in improved end-use quality and reduced gluten epitopes associated with celiac disease. Gliadins are important for wheat end-use traits.
( Liu et al., 2023 )

SDN1
CRISPR/Cas

China Agricultural University, China
Research Centre for Cereal and Industrial Crops, Italy

Traits related to increased plant yield and growth

Customize tomato cultivars for urban agriculture: increased compactness and decreased growth cycle of tomato plants.
(Kwon et al., 2020)

SDN1
CRISPR/Cas

Cold Spring Harbor Laboratory
Cornell University
University of Florida, USA
Wonkwang University, South Korea
Weizmann Institute of Science, Israel

Altered root architecture with increased tillers and total grain weight.
( Rahim et al., 2023 )

SDN1
CRISPR/Cas

Quaid-e-Azam University
National Agricultural Research Centre (NARC)
The University of Haripur, Pakistan
King Saud University, Saudi Arabia
Nile University
Ain Shams University, Egypt
Chonnam National University, South Korea

Increased leaf yield of lettuce by delaying the onset of flowering.
( Choi et al., 2022 )

SDN1
CRISPR/Cas

Korea Research Institute of Bioscience and Biotechnology
Korea University of Science and Technology, South Korea

Generating male sterility lines (MLS). Using MLS in hybrid seed production for monoclinous crops reduces costs and ensures high purity of the varieties because it does not produce pollen and has exserted stigmas. Complete abolition of pollen development.
( Lee et al., 2016 )

SDN1
CRISPR/Cas

Kyung Hee University, South Korea

Root growth angle regulation, among the most important determinants of root system architecture. Root growth angle controls water uptake capacity, stress resilience, nutrient use efficiency and thus yield of crop plants.
( Kirschner et al., 2021 )

SDN1
CRISPR/Cas

University of Bonn
University of Cologne
Leibniz Institute of Plant Genetics and Crop Plant Research Gatersleben
Justus-Liebig-University Giessen, Germany
University of Bologna, Italy

Altered spike architecture.
( de Souza Moraes et al., 2022 )

SDN1
CRISPR/Cas

Wageningen University and Research, The Netherlands
Universidade de São Paulo, Brazil
Norwich Research Park, UK
Rheinische Friedrich-Wilhelms-Universität, Germany

Enhanced sink strength in tomato, improving fruit setting, and yield contents.
( Nam et al., 2022 )

SDN1
CRISPR/Cas

Pohang University of Science and Technology
Wonkwang University, South Korea

Combine agronomically desirable traits with useful traits present in wild lines. Threefold increase in fruit size and a tenfold increase in fruit number. Fruit lycopene accumulation is improved by 500% compared with the widely cultivated S. lycopersicum.
( Zsögön et al., 2018 )

SDN1
CRISPR/Cas

Universidade Federal de Viçosa
Universidade de São Paulo Paulo, Brazil
University of Minnesota, USA
Universität Münster, Germany

Increased grain yield without side effect.
( Gho et al., 2022 )

SDN1
CRISPR/Cas

Kyung Hee University, South Korea
International Rice Research Institute, Philippines

Delayed bolting.
( Shin et al., 2022 )

SDN1
CRISPR/Cas

Kyung Hee University, South Korea

Improved spikelet number per panicle led to increased grain yield per plant.
( Ludwig et al., 2023 )

SDN1
CRISPR/Cas

International Rice Research Institute (IRRI), Philippines
University of Pavia, Italy

Optimum increase in phloem-transportation capacity leads to improved sink strength in tomato to increase agricultural crop production.
( Nam et al., 2022 )

SDN1
CRISPR/Cas

Pohang University of Science and Technology
Wonkwang University, South Korea

Delayed bolting.
( Shin et al., 2022 )

SDN1
CRISPR/Cas

Kyung Hee University, South Korea

Traits related to industrial utilization

Bio-fuel production: Reduced lignin content, improves cell wall composition for production of bio-ethanol.
(Jung et al., 2016)

SDN1
TALENs

Korea University, South Korea
University of Florida, USA

Higher haploid induction rate. Haploid induction allows formation of doubled haploids, which can be used to rapidly fix genetic information.
( Jang et al., 2023 )

SDN1
CRISPR/Cas

Chonnam National University
Pusan National University
Kyung Hee University, South Korea

Delayed flowering time.
( Hong et al., 2021 )

SDN1
CRISPR/Cas

National Institute of Agricultural Sciences, South Korea

Increased monounsaturated fatty acid contents (MUFAs). Due to their higher thermal-oxidative stability and viscosity relative to other common fatty acids, MUFAs are preferred for industrial uses, for example as biolubricants and biodiesel fuels.
( Lee et al., 2021 )

SDN1
CRISPR/Cas

National Institute of Agricultural Sciences
Korea Advanced Institute of Science and Technology
Chonnam National University
Plant Engineering Research Institute, South Korea

Early-flowering.
( Jeong et al., 2021 )

SDN1
CRISPR/Cas

Department of Biological Science
Seoul National University
Chungnam National University
Institute for Basic Science
Kangwon National University
Kyunghee University, South Korea

Improve biofuel production by mediating lignin modification. Lignocellulosic biomasses are an abundant renewable source of carbon energy. Heterogenous properties of lignocellulosic biomass and intrinsic recalcitrance caused by cell wall lignification lower the biorefinery efficiency. Reduced lignin content is desired.
( Lee et al., 2021 )

SDN1
CRISPR/Cas

Korea Institute of Science and Technology (KIST)
University of Science and Technology (UST)
Daejeon, South Korea

Accelerated domestication of African rice landraces by improving domestication traits such as sheed shattering, lodging and seed yield. The acceleration of the development of high-yield African landrace varieties is important considering that Africa has a strong growing population and prone to food shortage.
( Lacchini et al., 2020 )

SDN1
CRISPR/Cas

University of Milan, Italy
University of Montpellier, France

Bioethanol production: Improved saccharification efficiency without compromising biomass yield.
(Kannan et al., 2017)

SDN1
TALENs

University of Florida
Novozymes North America Inc, USA
Korea Institute of Science and Technology (KIST), South Korea

Generating male sterility lines (MLS). Using MLS in hybrid seed production reduces costs and ensures high purity of the varieties because it does not produce pollen and has exserted stigmas.
( Jung et al., 2020 )

SDN1
CRISPR/Cas

Hankyong National University
Hanyang University
Sunchon National University
Chungbuk National University
Tomato Research Center, South Korea

Removal of methyl iodide emissions. The release of methyl iodide in the athmospere causes ozone depletion and thus represents an important environmental threat.
( Carlessi et al., 2021 )

SDN1
CRISPR/Cas

PlantLab
Institute of Life Sciences
Scuola Superiore Sant’Anna
University of Pisa
University of Milan, Italy

Traits related to product color/flavour

Tangerine color
( Kim et al., 2022 )

SDN2
CRISPR/Cas

Hankyong National University
Korea Polar Research Institute
Chungbuk National University
Seoul National University College of Medicine
Hankyong National University, South Korea

Fine-tuned anthocyanin biosynthesis.
( )

SDN1
CRISPR/Cas

Northeast Forestry University, Horticultural Sub-academy of Heilongjiang Academy of Agricultural Sciences, China
Wonsan University of Agriculture, South Korea

Anthocyanin-rich and pigmented sweet oranges.
( Salonia et al., 2022 )

SDN1
CRISPR/Cas

Research Centre for Olive Fruit and Citrus Crops
University of Catania
Research and Innovation Centre Trento, Italy

Flower color modification to a pale purplish pink flower color compared to the purple violet wild type.
( Yu et al., 2021 )

SDN1
CRISPR/Cas

Hanyang University
Chungnam National University, South Korea

Brown color and increased sugar content.
( Kim et al., 2022 )

SDN1
CRISPR/Cas

Hankyong National University
Korea Polar Research Institute
Seoul National University College of Medicine
Chungbuk National University, South Korea

Traits related to storage performance

Delayed onset of riping.
( Jeon et al., 2024 )

SDN1
CRISPR/Cas

Kyungpook National University
Sunchon National University, South Korea

Enhancement of flowering time. Petunia has become popular in the floriculture industry, however it is sensitive to ethylene, which causes flower senescence.
( Xu et al., 2021 )

SDN1
CRISPR/Cas

Kyungpook National University
Kangwon National University, South Korea

Reduced fruit flesh browning. The browning of eggplant berry flesh after cutting has a negative impact on fruit quality for both industrial transformation and fresh consumption.
( Maioli et al., 2020 )

SDN1
CRISPR/Cas

University of Torino, Italy
Instituto de Biologica Molecular y Celular de Plantas (IBMCP)
Universitat Politècnica de València, Spain

Enhanced storage potential of ripening fruits.
( Do et al., 2024 )

SDN1
CRISPR/Cas

Kyungpook National University
Sunchon National University
Catholic University of Korea, South Korea

Traits categories

Genome Editing Technique

Countries

Plant

Sdn Type

Traits related to biotic stress tolerance

Traits related to abiotic stress tolerance

Traits related to improved food/feed quality

Traits related to increased plant yield and growth

Traits related to industrial utilization

Traits related to product color/flavour

Traits related to storage performance