genome search | EU-SAGE

Genome-editing techniques are promising tools in plant breeding. To facilitate a more comprehensive understanding of the use of genome editing, EU-SAGE developed an interactive, publicly accessible online database of genome-edited crop plants as described in peer-reviewed scientific publications.
The aim of the database is to inform interested stakeholder communities in a transparent manner about the latest evidence about the use of genome editing in crop plants. Different elements including the plant species, traits, techniques, and applications can be filtered in this database.
Regarding the methodology, a literature search in the bibliographic databases and web pages of governmental agencies was conducted using predefined queries in English. Identifying research articles in other languages was not possible due to language barriers. Patents were not screened.
Peer-reviewed articles were screened for relevance and were included in the database based on pre-defined criteria. The main criterium is that the research article should describe a research study of any crop plant in which a trait has been introduced that is relevant from an agricultural and/or food/feed perspective. The database does neither give information on the stage of development of the crop plant, nor on the existence of the intention to develop the described crop plants to be marketed.
This database will be regularly updated. Please contact us via the following webpage in case you would like to inform us about a new scientific study of crops developed for market-oriented agricultural production as a result of genome editing

Displaying 63 results

Traits related to biotic stress tolerance

Fungal resistance: Enhanced resistance to the pathogen Sclerotinia sclerotiorum.
(Sun et al., 2018)

SDN1
CRISPR/Cas

Yangzhou University, China

Fungal resistance: increased resistance to Erysiphe necator, causing powdery mildew in grape cultivar. The pathogen infects all green tissues and berries, leading to dramatic losses in yield and berry quality.
(Malnoy et al., 2016)

SDN1
CRISPR/Cas

Fondazione Edmund Mach, Italy
ToolGen Inc.
Institute for Basic Science
Seoul National University, South Korea

Fungal resistance: contribute to Sclerotinia sclerotiorum resistance.
(Zhang et al., 2022)

SDN1
CRISPR/Cas

Huazhong Agricultural University, China

Oilseed rape mutant with non-abscising floral organs. Clerotinia stem rot (SSR), caused by Sclerotinia sclerotiorum is a detrimental fungal disease for oilseed rape. Petal infection is crucial to the prevalence of SSR in oilseed rape. Oilseed rape varieties with abscission-defective ﬂoral organs were predicted to be less susceptible to Sclerotinia infection and to have a longer ﬂowering period to enhance tourism income.
( Wu et al., 2022 )

SDN1
CRISPR/Cas

Yangzhou University, China

Viral resistance: Resistance against Grapevine leafroll-associated virus 3 (GLRaV-3), which is one of the causal agents of grapevine leafroll disease (GLD). GLD severely impacts grapevine production.
(Jiao et al., 2022)

CRISPR/Cas

Northwest A&
F University, China

Fungal resistance: enhanced resistance to powdery mildew (Erysiphe necator), a major fungal disease, threatening one of the most economically valuable horticular crops.
(Wan et al., 2020)

SDN1
CRISPR/Cas

Ministry of Agriculture, China
Northwest A&
F University
University of Maryland College Park, USA

Fungal resistance: reduced susceptibility to Verticillium longisporum, a pathogen causing Verticillium stem striping. No fungicide treatments are currently available to control this disease.
(Pröbsting et al., 2020)

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel
Institut für Zuckerrübenforschung
NPZ Innovation GmbH, Germany

Visualization of the early stages of Cassava bacterial blight (CBB) infection in vivo. CBB is caused by Xanthomonas axonopodis pv. Manihotis.
( Veley et al., 2021 )

SDN2
CRISPR/Cas

Donald Danforth Plant Science Center, USA
National Root Crops Research Institute, Nigeria

Viral resistance: reduced cassava brown streak disease (CBSD) symptom severity and incidence. CBSD threatens cassava production in West Africa and is a major constraint on cassava production in East and Central Africa.
(Gomez et al., 2019)

SDN1
CRISPR/Cas

University of California
Donald Danforth Plant Science Center, USA

Bacterial resistance: Xanthomonas citri, causing citrus canker, one of the most serious diseases affecting the global citrus industry. Citrus is the most produced fruit in the world.
(Jia et al., 2016)

SDN1
CRISPR/Cas

University of Florida, USA

Bacterial resistance: resistance to Xanthomonas citri, a pathogen causing citrus canker. Citrus canker is one of the most devastating citrus diseases worldwide, causing canker symptoms. Generating disease-resistant varieties is one of the most efficient and environmentally friendly measures for controlling canker.
(Jia et al., 2021)

SDN1
CRISPR/Cas

University of Florida
Citrus Research and Education Center, USA

Fungal resistance: increased resistance to Botrytis cinerea.
(Wang et al., 2018)

SDN1
CRISPR/Cas

Northwest A&
F University and Ministry of Agriculture, China

Rapid detection of Sclerotium rolfsii, the causal agent of stem and root rot disease. This technique is effective for identification of pathogens, with potential for on-site testing.
( Changtor et al., 2023 )

SDN1
CRISPR/Cas

Naresuan University, Thailand

Fungal resistance: effective reduction of susceptibility against downy mildew by increasing salicylic acid levels. The pathogen can devastate individual vineyards and in some cases also affect production from entire regions.
(Giacomelli et al., 2023)

SDN1
CRISPR/Cas

Research and Innovation Centre
Fondazione Edmund Mach, Italy
Enza Zaden
Hudson River Biotechnology, The Netherlands

Visual detection of brassica yellows virus (BrYV), an economically important virus on cruciferous species. This assay allows for convenient, portable, rapid, low-cost, highly sensitive and specific detection and has great potential for on-site monitoring of BrYV.
( Xu et al., 2023 )

SDN1
CRISPR/Cas

Guizhou University, China

Resistance against a protist pathogen: stable resistance against clubroot disease. Clubroot disease is caused by the protist Plasmodiophora brassicae Woronin and can result in a 10-15% yield loss in Brassica species as well as related crops.
(Hu et al., 2023)

SDN1
CRISPR/Cas

Saskatoon Research and Development Centre, Canada

Fungal resistance: Decreased susceptibility to Plasmopara viticola, the causing agent of the grapevine downy mildew.
(Djennane et al., 2023)

SDN1
CRISPR/Cas

Université de Strasbourg
Institut Jean-Pierre Bourgin (IJPB), France

Fungal resistance: Reduced susceptibility to Verticillium longisporum, fungal pathogen that causes stem striping in Brassica napus and leads to huge yield losses.
(Ye et al., 2024)

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel
Institut für Zuckerrübenforschung
Hohenlieth-Hof, NPZ Innovation GmbH, Germany
Aswan University, Egypt
Fujian Agriculture and Forestry University, China

Fungal resistance: reduced symptoms caused by a powedry mildew infection.
(Olivares et al., 2021)

SDN1
CRISPR/Cas

National Institute of Agriculture Research, Chile

Traits related to abiotic stress tolerance

Reduced stomatal density. Intrinsic water-use efficiency was significantly impacted under both well-watered and drought conditions, making reduced stomatal density as a preferable trait.
( Clemens et al., 2022 )

SDN1
CRISPR/Cas

University of California
San Diego State University, USA

Enhanced drought tolerance
( Wu et al., 2020 )

SDN1
CRISPR/Cas

Huazhong Agricultural University, China

Reduction in cadmium accumulation. Cadmium is a heavy metal, harmful for human health.
( Yao et al., 2022 )

SDN1
CRISPR/Cas

Sichuan University
Science and Technology Innovation Center of Sichuan Modern Seed Industry Group, China

Improved drought tolerance.
( Linghu et al., 2023 )

SDN1
CRISPR/Cas

Hybrid Rapeseed Research Center of Shaanxi Province
Northwest A &
F University, China

Traits related to improved food/feed quality

Low tartaric acid.
( Ren et al., 2016 )

SDN1
CRISPR/Cas

University of Chinese Academy of Sciences
Chinese Academy of Sciences, China

Promoted anthocyanin accumulation. Anthocyanins are plant secondary metabolites with a variety of biological functions.
( Tu et al., 2022 )

SDN1
CRISPR/Cas

Northwest A&
F University, China

Improved fatty acid content: increased content of oleic acid, reduced erucic acid levels and slightly decreased polyunsaturated fatty acids content. Fatty acid composition is important for human health and shelf life.
(Shi et al., 2022)

SDN1
CRISPR/Cas

Zhejiang Academy of Agricultural Sciences, China

Modified fatty acid profile: increased oleic acid, decreased linoleic and linolenic acid content.
(Huang et al., 2020)

SDN1
CRISPR/Cas

National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, China

Yellow-seed production, a desirable trait with great potential for improving seed quality in Brassica crops. The formation of seed colour is due to the deposition of the oxidized form of a flavonoid, called proanthocyanidins (PA). Yellow seeds have a higher oil content.
( Zhai et al., 2019 )

SDN1
CRISPR/Cas

Huazhong Agricultural University, China

High-amylose content (up to 56% in apparent amylose content) and resistant starch (up to 35%).
( Luo et al., 2021 )

SDN1
CRISPR/Cas

Chinese Academy of Sciences
Shanghai Sanshu Biotechnology Co.,
Guangxi Subtropical Crops Research Institute, China

Attenuated toxic cyanogen production. Cassava produces toxic cyanogenic compounds and requires food processing for safe consumption.
( Gomez et al., 2021 )

SDN1
CRISPR/Cas

University of California
Donald Danforth Plant Science Center
Lawrence Berkeley National Laboratory
Okinawa Institute of Science and Technology Graduate University
Chan-Zuckerberg BioHub, USA

Reduction of phytic acid (PA) in seeds. PA has adverse effects on essential mineral absorption and thus is considered as an anti-nutritive for monogastric animals.
( Sashidhar et al., 2020 )

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel
Max-Planck-Institute for Evolutionary Biology, Germany

Altered lignin composition: decreased syringyl monolignol / guaiacylmonolignol (S/G) ratio. The monolignol ratio has been proposed to affect biomass recalcitrance and the resistance to plant disease.
(Cao et al., 2021)

SDN1
CRISPR/Cas

SouthwestUniversity, China
University of Wisconsin, USA

Increasing seed oil content (SOC).
( Zhang et al., 2022 )

SDN1
CRISPR/Cas

Huazhong University of Science and Technology, China

Improved fatty acid composition. The content and abundance of fatty acids play an important role in nutritional and processing applications of oilseeds.
( Okuzaki et al., 2018 )

SDN1
CRISPR/Cas

Tamagawa University
Osaka Prefecture University
Tamagawa University, Japan

Decreases in palmitic acid, increased total C18 and reduced total saturated fatty acid contents. Reduced saturated fat content is connected to lowered cardiovascular disease rate.
( Gupta et al., 2012 )

SDN1
ZFN

Dow AgroSciences
Sangamo BioSciences, USA

Reduced flavonoids and improved fatty acid composition with higher linoleic acid and linolenic acid, valuable for rapeseed germplasm and breeding. The genetic improvement has great significance in the economic value of rapeseeds.
( Xie et al., 2020 )

SDN1
CRISPR/Cas

Yangzhou University
The Ministry of Education of China, China
University of Western Australia, Australia

Reduce or eliminate amylose content in root starch. Amylose influences the physicochemical properties of starch during cooking and processing.
( Bull et al., 2018 )

SDN1
CRISPR/Cas

Institute of Molecular Plant Biology, Switzerland

Low erucic acid (EA) content. Composition of fatty acids affects the edible and processing quality of vegetable oils. EA is potentially to cause health problems.
( Liu et al., 2022 )

SDN1
CRISPR/Cas

Huazhong Agricultural University, China

Improved seed oil content: increased levels of monounsaturated fatty acids and decreased levels of polyunsaturated fatty acids.
(Wang et al., 2022)

SDN1
CRISPR/Cas

Huazhong Agricultural University, China
National Research Council Canada, Canada

Traits related to increased plant yield and growth

Increased shatter resistance to avoid seed loss during mechanical harvest.
( Braatz et al., 2017 )

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel, Germany

Increased seeds number per husk, higher seed weight.
( Yang et al., 2018 )

SDN1
CRISPR/Cas

Huazhong Agricultural University, China

Confer shoot architectural changes for increased resource inputs to increase crop yield.
( Stanic et al., 2021 )

SDN1
CRISPR/Cas

University of Calgary, Canada
SRM Institute of Technology, India

Improve plant architecture to increase yield. Plant height and branch number are directly correlated with yield.
( Zheng et al., 2020 )

SDN1
CRISPR/Cas

Ministry of Agriculture, China
Wilkes University, USA

Semi-dwarf phenotype and compact architecture to increase yield. Plant height and branch angle are the major architectural factors determining yield.
( Fan et al., 2021 )

SDN1
CRISPR/Cas

Ministry of Agriculture and Rural Affairs, China
Wilkes University, USA

Early-flowering varieties. The timing of flowering is an important event in the life cycle of flowering plants.
( Jiang et al., 2018 )

SDN1
CRISPR/Cas

Hunan Agricultural University, China
Université de Strasbourg, France

Increased seed oil content (SOC). SOC is a major determinant of yield and quality.
( Karunarathna et al., 2020 )

SDN1
CRISPR/Cas

Christian-Albrechts-University of Kiel, Germany
Zhejiang University, China

Traits related to industrial utilization

Establishment of maternal haploid induction. Doubled haploid technology is used to obtain homozygous lines in a single generation. This technique significantly accelerates the crop breeding trajectory.
( Zhong et al., 2022 )

SDN1
CRISPR/Cas

China Agricultural University, China
Wageningen University and Research, The Netherlands

Manipulation of flowering time to develop cultivars with desired maturity dates. Stabilization of flowering time and period supports efficient mechanised harvesting.
( Ahmar et al., 2021 )

SDN1
CRISPR/Cas

Huazhong Agricultural University, China

Self-incompatibility to prevent inbreeding in hermaphrodite angiosperms via the rejection of self-pollen.
( Dou et al., 2021 )

SDN1
CRISPR/Cas

Huazhong Agricultural University, China

Accelerate flowering, a rare event under glasshouse conditions. Modified starch.
( Bull et al., 2018 )

SDN3
CRISPR/Cas

Institute of Molecular Plant Biology, Switzerland

Confer male and female sterility to prevent the risk of trasgene flow from transgenic plants to their wild relatives.
( Shinoyama et al., 2020 )

SDN1
TALENs

Fukui Agricultural Experiment Station
Institute of Agrobiological Sciences
National Agriculture and Food Research Organization (NARO)
Japan Science and Technology Agency (JST)
Yokohama City University, Japan
Altai State University, Russia

Generating genic male sterility lines (GMS). GMS can promote heterosis in rapeseed. Compared with other approaches, GMS brings about nearly complete male sterility to a hybrid breeding program.
( Wang et al., 2023 )

SDN1
CRISPR/Cas

Northwest A&
F University
Hybrid Rapeseed Research Centre of Shaanxi Province, China

Reversible complete male sterility. Very precise hormone mediated control of male fertility transition showed great potential for hybrid seed production in Brassica species crops.
( Cheng et al., 2023 )

SDN1
CRISPR/Cas

Ministry of Agriculture and Rural Affairs
Henan Normal University, China

Male sterility.
( Tu et al., 2024 )

SDN1
CRISPR/Cas

Zhejiang University
Jiaxing Academy of Agricultural Sciences, China

Male sterility.
( Shen et al., 2024 )

SDN1
CRISPR/Cas

Huazhong Agricultural University
Hubei Hongshan Laboratory, China

Traits related to herbicide tolerance

Herbicide tolerance: AHAS-inhibiting
(Gocal et al., 2015)

ODM

Cibus, Canada
Cibus, USA

Herbicide tolerance: glyphosate
(Hummel et al., 2017)

SDN3
CRISPR/Cas

Donald Danforth Plant Science Center, St. Louis, USA

Glyphosate
( Wang et al., 2021 )

CRISPR/Cas

Huazhong Agricultural University
Anhui Academy of Agricultural Sciences, China

Tribenuron methyl
( Wu et al., 2020 )

Yangzhou University
Shanghai Normal University, China

Traits related to product color/flavour

Altered color of petals and leaves.
( Li et al., 2022 )

SDN1
CRISPR/Cas

Huazhong Agricultural University
Hubei Hongshan Laboratory, China

Colour shift. The poinsettia belongs to most economically important potted ornamental plants. Customers are willing to pay higher prices for unusual varieties.
( Nitarska et al., 2021 )

SDN1
CRISPR/Cas

Technische Universität Wien, Austria
Klemm+Sohn GmbH &
Co
Leibniz Universität Hannover, Germany

Yellow colored seed.
( Huang et al., 2023 )

SDN1
CRISPR/Cas

Hunan Academy of Agricultural Sciences
Hunan University of Science and Technology
Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, China

Traits related to storage performance

Extended root shelf-life, which decreases its wastage.
( Mukami et al., 2023 )

SDN1
CRISPR/Cas

Kenyatta University
Jomo Kenyatta University of Agriculture Technology
Pwani University Kilifi, Kenya

Traits categories

Genome Editing Technique

Countries

Plant

Sdn Type

Traits related to biotic stress tolerance

Traits related to abiotic stress tolerance

Traits related to improved food/feed quality

Traits related to increased plant yield and growth

Traits related to industrial utilization

Traits related to herbicide tolerance

Traits related to product color/flavour

Traits related to storage performance